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Gene Review

SOX14  -  SRY (sex determining region Y)-box 14

Homo sapiens

Synonyms: Protein SOX-28, SOX28, Transcription factor SOX-14
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Disease relevance of SOX14


High impact information on SOX14


Biological context of SOX14

  • The minimal SOX14 promoter region that confers the basal promoter activity, as well as a proximal enhancer, was determined using promoter-reporter constructs [4].

Anatomical context of SOX14

  • SOX14 is expressed in human foetal brain, spinal cord and thymus, and like other members of the B subfamily, it might have a role in regulation of nervous system development [3].

Other interactions of SOX14


  1. SOX14 is a candidate gene for limb defects associated with BPES and Möbius syndrome. Wilmore, H.P., Smith, M.J., Wilcox, S.A., Bell, K.M., Sinclair, A.H. Hum. Genet. (2000) [Pubmed]
  2. Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases. Hargrave, M., James, K., Nield, K., Toomes, C., Georgas, K., Sullivan, T., Verzijl, H.T., Oley, C.A., Little, M., De Jonghe, P., Kwon, J.M., Kremer, H., Dixon, M.J., Timmerman, V., Yamada, T., Koopman, P. Hum. Genet. (2000) [Pubmed]
  3. Characterisation and mapping of the human SOX14 gene. Arsic, N., Rajic, T., Stanojcic, S., Goodfellow, P.N., Stevanovic, M. Cytogenet. Cell Genet. (1998) [Pubmed]
  4. Structural and functional characterization of the human SOX14 promoter. Djurovic, J., Stevanovic, M. Biochim. Biophys. Acta (2004) [Pubmed]
  5. Cloning and mapping of platypus SOX2 and SOX14: insights into SOX group B evolution. Kirby, P.J., Waters, P.D., Delbridge, M., Svartman, M., Stewart, A.N., Nagai, K., Graves, J.A. Cytogenet. Genome Res. (2002) [Pubmed]
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