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Gene Review:

CMF1 - cardiac muscle factor 1

Gallus gallus

This record was replaced with 395357.

Redkar, A. et al., Goodwin, R.L. et al., Pabón-Peña, L.M. et al., Yang, Z.Y. et al.

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Disease relevance of CMF1

Characterization of cardiac muscle factor 1 sequence motifs: retinoblastoma protein binding and nuclear localization [1].

High impact information on CMF1

Analysis of CMF1 reveals a bone morphogenetic protein-independent component of the cardiomyogenic pathway [2].
Disruption of the CMF1 function in anterior mesoderm inhibits cardiac myogenesis in avian embryos [2].
From these data, we hypothesize that chicken CMF1, human CENP-F, mitosin, and mouse LEK1 are members of an emerging family of genes that have important and functionally distinct roles in development and cell division [3].
Cardiac muscle factor 1 (CMF1) is characterized as a protein important in cardiac and skeletal myocyte differentiation and is expressed in a developmentally regulated manner [1].
LEK1 and CMF1, which are its murine and chicken orthologs, however, are implicated in muscle differentiation and reportedly not distributed at kinetochores [4].

References

Characterization of cardiac muscle factor 1 sequence motifs: retinoblastoma protein binding and nuclear localization. Redkar, A., deRiel, J.K., Xu, Y.S., Montgomery, M., Patwardhan, V., Litvin, J. Gene (2002) [Pubmed]
Analysis of CMF1 reveals a bone morphogenetic protein-independent component of the cardiomyogenic pathway. Pabón-Peña, L.M., Goodwin, R.L., Cise, L.J., Bader, D. J. Biol. Chem. (2000) [Pubmed]
The cloning and analysis of LEK1 identifies variations in the LEK/centromere protein F/mitosin gene family. Goodwin, R.L., Pabón-Peña, L.M., Foster, G.C., Bader, D. J. Biol. Chem. (1999) [Pubmed]
Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Yang, Z.Y., Guo, J., Li, N., Qian, M., Wang, S.N., Zhu, X.L. Cell Res. (2003) [Pubmed]

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