The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

CMF1  -  cardiac muscle factor 1

Gallus gallus

This record was replaced with 395357.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CMF1


High impact information on CMF1

  • Analysis of CMF1 reveals a bone morphogenetic protein-independent component of the cardiomyogenic pathway [2].
  • Disruption of the CMF1 function in anterior mesoderm inhibits cardiac myogenesis in avian embryos [2].
  • From these data, we hypothesize that chicken CMF1, human CENP-F, mitosin, and mouse LEK1 are members of an emerging family of genes that have important and functionally distinct roles in development and cell division [3].
  • Cardiac muscle factor 1 (CMF1) is characterized as a protein important in cardiac and skeletal myocyte differentiation and is expressed in a developmentally regulated manner [1].
  • LEK1 and CMF1, which are its murine and chicken orthologs, however, are implicated in muscle differentiation and reportedly not distributed at kinetochores [4].


  1. Characterization of cardiac muscle factor 1 sequence motifs: retinoblastoma protein binding and nuclear localization. Redkar, A., deRiel, J.K., Xu, Y.S., Montgomery, M., Patwardhan, V., Litvin, J. Gene (2002) [Pubmed]
  2. Analysis of CMF1 reveals a bone morphogenetic protein-independent component of the cardiomyogenic pathway. Pabón-Peña, L.M., Goodwin, R.L., Cise, L.J., Bader, D. J. Biol. Chem. (2000) [Pubmed]
  3. The cloning and analysis of LEK1 identifies variations in the LEK/centromere protein F/mitosin gene family. Goodwin, R.L., Pabón-Peña, L.M., Foster, G.C., Bader, D. J. Biol. Chem. (1999) [Pubmed]
  4. Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Yang, Z.Y., Guo, J., Li, N., Qian, M., Wang, S.N., Zhu, X.L. Cell Res. (2003) [Pubmed]
WikiGenes - Universities