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Gene Review

BMP1  -  bone morphogenetic protein 1

Gallus gallus

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Disease relevance of BMP1


Psychiatry related information on BMP1

  • Inhibition of either RA or BMP signaling, with selective inhibitors, interfered with the inductive effects of these agents but also inhibited the complementary pathway, demonstrating a codependence of RA and BMP signaling during chondrocyte maturation [4].

High impact information on BMP1


Biological context of BMP1


Anatomical context of BMP1


Associations of BMP1 with chemical compounds


Other interactions of BMP1


Analytical, diagnostic and therapeutic context of BMP1

  • In contrast to bone morphogenetic proteins extracted from demineralized bone or overexpressed in cell culture, the refolded Escherichia coli-expressed protein is not glycosylated at a conserved N-linked site and is therefore homogeneous [22].
  • No alterations in the expression of mRNAs for BMP-1 to -8 were observed in the C3H10T1/2 cells under any of the coculture conditions [23].
  • Interestingly, we have found that several bone morphogenetic proteins can be detected in developing embryonic day 14 rat dorsal root ganglia by means of reverse transcription-polymerase chain reaction and immunocytochemistry [3].


  1. Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly. Golden, J.A., Bracilovic, A., McFadden, K.A., Beesley, J.S., Rubenstein, J.L., Grinspan, J.B. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Growth plate chondrocyte maturation is regulated by basal intracellular calcium. Zuscik, M.J., D'Souza, M., Ionescu, A.M., Gunter, K.K., Gunter, T.E., O'Keefe, R.J., Schwarz, E.M., Puzas, J.E., Rosier, R.N. Exp. Cell Res. (2002) [Pubmed]
  3. Characterization of bone morphogenetic protein family members as neurotrophic factors for cultured sensory neurons. Farkas, L.M., Jászai, J., Unsicker, K., Krieglstein, K. Neuroscience (1999) [Pubmed]
  4. Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. Li, X., Schwarz, E.M., Zuscik, M.J., Rosier, R.N., Ionescu, A.M., Puzas, J.E., Drissi, H., Sheu, T.J., O'Keefe, R.J. Endocrinology (2003) [Pubmed]
  5. The status of Wnt signalling regulates neural and epidermal fates in the chick embryo. Wilson, S.I., Rydström, A., Trimborn, T., Willert, K., Nusse, R., Jessell, T.M., Edlund, T. Nature (2001) [Pubmed]
  6. Estrogen opposes the apoptotic effects of bone morphogenetic protein 7 on tissue remodeling. Monroe, D.G., Jin, D.F., Sanders, M.M. Mol. Cell. Biol. (2000) [Pubmed]
  7. BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo. Schlange, T., Arnold, H.H., Brand, T. Development (2002) [Pubmed]
  8. Bone morphogenetic proteins negatively control oligodendrocyte precursor specification in the chick spinal cord. Mekki-Dauriac, S., Agius, E., Kan, P., Cochard, P. Development (2002) [Pubmed]
  9. BMP-2/-4 mediate programmed cell death in chicken limb buds. Yokouchi, Y., Sakiyama, J., Kameda, T., Iba, H., Suzuki, A., Ueno, N., Kuroiwa, A. Development (1996) [Pubmed]
  10. Distinctive expression patterns of heparan sulfate O-sulfotransferases and regional differences in heparan sulfate structure in chick limb buds. Nogami, K., Suzuki, H., Habuchi, H., Ishiguro, N., Iwata, H., Kimata, K. J. Biol. Chem. (2004) [Pubmed]
  11. Chick limb bud mesodermal cell chondrogenesis: inhibition by isoforms of platelet-derived growth factor and reversal by recombinant bone morphogenetic protein. Chen, P., Carrington, J.L., Paralkar, V.M., Pierce, G.F., Reddi, A.H. Exp. Cell Res. (1992) [Pubmed]
  12. Significance of bone morphogenetic protein-4 function in the initial myofibrillogenesis of chick cardiogenesis. Nakajima, Y., Yamagishi, T., Ando, K., Nakamura, H. Dev. Biol. (2002) [Pubmed]
  13. Expression and regulation of Groucho-related genes in the embryonic chicken feather bud. Houghton, L., Freeman, A., Morgan, B.A. Dev. Dyn. (2003) [Pubmed]
  14. Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues. Reynolds, S.D., Zhang, D., Puzas, J.E., O'Keefe, R.J., Rosier, R.N., Reynolds, P.R. Gene (2000) [Pubmed]
  15. Sensory organ generation in the chick inner ear. Wu, D.K., Oh, S.H. J. Neurosci. (1996) [Pubmed]
  16. Osteogenin (bone morphogenetic protein-3) stimulates cartilage formation by chick limb bud cells in vitro. Carrington, J.L., Chen, P., Yanagishita, M., Reddi, A.H. Dev. Biol. (1991) [Pubmed]
  17. Bone morphogenetic protein-7 in growth-plate chondrocytes: regulation by retinoic acid is dependent on the stage of chondrocyte maturation. Grimsrud, C.D., Rosier, R.N., Puzas, J.E., Reynolds, P.R., Reynolds, S.D., Hicks, D.G., O'Keefe, R.J. J. Orthop. Res. (1998) [Pubmed]
  18. Analysis of CMF1 reveals a bone morphogenetic protein-independent component of the cardiomyogenic pathway. Pabón-Peña, L.M., Goodwin, R.L., Cise, L.J., Bader, D. J. Biol. Chem. (2000) [Pubmed]
  19. FGF10 is a mesenchymally derived stimulator for epidermal development in the chick embryonic skin. Tao, H., Yoshimoto, Y., Yoshioka, H., Nohno, T., Noji, S., Ohuchi, H. Mech. Dev. (2002) [Pubmed]
  20. BMP signaling during bone pattern determination in the developing limb. Kawakami, Y., Ishikawa, T., Shimabara, M., Tanda, N., Enomoto-Iwamoto, M., Iwamoto, M., Kuwana, T., Ueki, A., Noji, S., Nohno, T. Development (1996) [Pubmed]
  21. Regulation of chondrocyte terminal differentiation in the postembryonic growth plate: the role of the PTHrP-Indian hedgehog axis. Farquharson, C., Jefferies, D., Seawright, E., Houston, B. Endocrinology (2001) [Pubmed]
  22. Biochemical and biophysical characterization of refolded Drosophila DPP, a homolog of bone morphogenetic proteins 2 and 4. Groppe, J., Rumpel, K., Economides, A.N., Stahl, N., Sebald, W., Affolter, M. J. Biol. Chem. (1998) [Pubmed]
  23. Chondrocytes provide morphogenic signals that selectively induce osteogenic differentiation of mesenchymal stem cells. Gerstenfeld, L.C., Cruceta, J., Shea, C.M., Sampath, K., Barnes, G.L., Einhorn, T.A. J. Bone Miner. Res. (2002) [Pubmed]
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