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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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SLC4A2  -  solute carrier family 4 (anion exchanger),...

Gallus gallus

 
 
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High impact information on AE2

  • In contrast, the anion exchanger (AE2), a marker protein of the basal-lateral plasma membrane in the choroid plexus, did not cosediment in sucrose gradients or comigrate in nondenaturing polyacrylamide gels with the complex of Na+,K(+)-ATPase, ankyrin, and fodrin [1].
  • In situ hybridization analyses have further revealed that AE2 transcripts accumulate to very high levels within the acid-secreting epithelial cells of the profound gland in the stomach and, to a lesser extent, within the mucus-secreting cells of the superficial gland that line the stomach lumen [2].
  • Variant AE2 anion exchanger transcripts accumulate in multiple cell types in the chicken gastric epithelium [2].
  • The approximately 4.3-kilobase (kb) AE2-1 cDNA contains an open reading frame that encodes a predicted polypeptide of approximately 135 kDa that is homologous to AE2 anion exchangers from other species [2].
  • AE1-, AE2-, or AE3-positive alpha-keratins are present in different epidermal layers with a pattern similar to that previously described in reptiles [3].

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