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Gene Review

Slc4a2  -  solute carrier family 4 (anion exchanger),...

Mus musculus

Synonyms: AE 2, Ae2, Anion exchange protein 2, Anion exchanger 2, B3RP, ...
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High impact information on Slc4a2

  • Among the four AE genes identified in mammals thus far, only Ae2 (Slc4a2) has been determined to be expressed in the male reproductive system, especially in developing spermatozoa and in epididymal epithelium [1].
  • Here, we generated mice carrying a targeted disruption of Ae2 that prevents the expression of the three AE2 isoforms (Ae2a, Ae2b1, and Ae2b2) normally found in mouse testes [1].
  • Our findings reveal an essential role of Ae2 in mouse spermiogenesis and stress the recently postulated involvement of bicarbonate in germ-cell differentiation through the bicarbonate-sensitive soluble-adenylyl-cyclase pathway [1].
  • In parietal cells, basolateral Ae2 Cl(-)/HCO(3)(-) exchanger (Slc4a2) appears to compensate for luminal H(+) pumping while providing Cl(-) for apical secretion [2].
  • In the oxyntic mucosa of Ae2(a,b)(-/-) mice, total Ae2 protein was nearly undetectable, indicating low gastric expression of the Ae2c isoforms [2].

Biological context of Slc4a2

  • The carboxyl-terminal hydrophobic domain of B3RP has an amino acid sequence 67% identical to that of band 3, with a very similar predicted secondary structure [3].

Anatomical context of Slc4a2


Associations of Slc4a2 with chemical compounds


Other interactions of Slc4a2

  • The other, far amino-terminal section of B3RP has no correspondent in the band 3 sequence [3].

Analytical, diagnostic and therapeutic context of Slc4a2


  1. Anion exchanger 2 is essential for spermiogenesis in mice. Medina, J.F., Recalde, S., Prieto, J., Lecanda, J., Saez, E., Funk, C.D., Vecino, P., van Roon, M.A., Ottenhoff, R., Bosma, P.J., Bakker, C.T., Elferink, R.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Inefficient chronic activation of parietal cells in Ae2a,b(-/-) mice. Recalde, S., Muruzábal, F., Looije, N., Kunne, C., Burrell, M.A., Sáez, E., Martínez-Ansó, E., Salas, J.T., Mardones, P., Prieto, J., Medina, J.F., Elferink, R.P. Am. J. Pathol. (2006) [Pubmed]
  3. Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line. Alper, S.L., Kopito, R.R., Libresco, S.M., Lodish, H.F. J. Biol. Chem. (1988) [Pubmed]
  4. Immunolocalization and tissue-specific splicing of AE2 anion exchanger in mouse kidney. Stuart-Tilley, A.K., Shmukler, B.E., Brown, D., Alper, S.L. J. Am. Soc. Nephrol. (1998) [Pubmed]
  5. Proteolytic cleavage sites of native AE2 anion exchanger in gastric mucosal membranes. Zolotarev, A.S., Chernova, M.N., Yannoukakos, D., Alper, S.L. Biochemistry (1996) [Pubmed]
  6. NH4Cl activates AE2 anion exchanger in Xenopus oocytes at acidic pHi. Humphreys, B.D., Chernova, M.N., Jiang, L., Zhang, Y., Alper, S.L. Am. J. Physiol. (1997) [Pubmed]
  7. Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Shmukler, B.E., Kurschat, C.E., Ackermann, G.E., Jiang, L., Zhou, Y., Barut, B., Stuart-Tilley, A.K., Zhao, J., Zon, L.I., Drummond, I.A., Vandorpe, D.H., Paw, B.H., Alper, S.L. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  8. Molecular cloning and genomic organization of the mouse AE2 anion exchanger gene. Lecanda, J., Urtasun, R., Medina, J.F. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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