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Gene Review

SIX6  -  SIX homeobox 6

Gallus gallus

Synonyms: OPTX2, Six9
 
 
 
 
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High impact information on SIX6

  • Optx2 expression is turned off in the future pigment epithelium but remains expressed in the proliferating neuroblasts and differentiating cells of the neural retina [1].
  • When an Optx2-expressing plasmid is transfected into embryonic or mature chicken pigment epithelial cells, these cells adopt a neuronal morphology and express markers characteristic of developing neural retina and photoreceptors [1].
  • The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes [1].

References

  1. The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes. Toy, J., Yang, J.M., Leppert, G.S., Sundin, O.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
 
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