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Gene Review

SMO  -  smoothened, frizzled family receptor

Gallus gallus

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High impact information on SMO

  • This effect of Shh was not mediated by Patched (Ptc) and Smoothened (Smo), the receptors that mediate effects of Shh in morphogenesis and commissural axon growth toward the floor plate [1].
  • We develop a model to study the effects of two forms of Shh used experimentally and propose a mechanism for Shh signal transduction based on a two-state model for the Ptc-Smo interaction [2].
  • We also describe genetic mapping of gli1, ptc, shh and smoothened in chickens and confirm by co-segregation analysis that none of these genes correspond to talpid3 [3].
  • Crescent encodes a protein that in its N-terminal half shows the characteristic invariant 9 cysteine residues of the cysteine-rich domain (CRD) found in the Frizzled family of proteins, in Smoothened and in Collagen XVIII [4].


  1. Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord. Bourikas, D., Pekarik, V., Baeriswyl, T., Grunditz, A., Sadhu, R., Nardó, M., Stoeckli, E.T. Nat. Neurosci. (2005) [Pubmed]
  2. Short- and long-range effects of Sonic hedgehog in limb development. Dillon, R., Gadgil, C., Othmer, H.G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway. Lewis, K.E., Drossopoulou, G., Paton, I.R., Morrice, D.R., Robertson, K.E., Burt, D.W., Ingham, P.W., Tickle, C. Development (1999) [Pubmed]
  4. Crescent, a novel chick gene encoding a Frizzled-like cysteine-rich domain, is expressed in anterior regions during early embryogenesis. Pfeffer, P.L., De Robertis, E.M., Izpisua-Belmonte, J.C. Int. J. Dev. Biol. (1997) [Pubmed]
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