The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Smo  -  smoothened, frizzled class receptor

Rattus norvegicus

Synonyms: SMO, Smoh, Smoothened homolog
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Smo

  • Adult rat-derived hippocampal progenitor cells express many of the molecules implicated in midbrain dopaminergic determination, including FGF receptors 1, 2 and 3, the sonic hedgehog receptor components Smo and Ptc, and the region-specific transcription factors Ptx3 and Nurr1 [1].
  • Transcripts for the putative Shh-receptor genes patched (Ptc) and smoothened (Smo) are expressed by embryonic, postnatal, and adult progenitor cells, suggesting that Shh can act directly on these cells [2].
  • In situ hybridization experiments using specific digoxigenin-labeled riboprobes showed expression of Ptc and Smo transcripts in discrete brain areas [3].
  • Interestingly, Smo transcripts were predominantly present within circumventricular organs, in granular cells of the dentate gyrus and in neurons of the reticular thalamic nucleus [4].
  • We have performed a detailed localization of cells expressing transcripts of Shh, Ptc, Smo and Gli1 in brain and spinal cord of the adult rat as well as in the developing cerebellum [4].

Anatomical context of Smo


Physical interactions of Smo

  • These observations suggest that in the adult brain, Shh signals through its receptor complex Ptc/Smo, or through Ptc alone [5].

Other interactions of Smo

  • This receptor for Shh is associated with Smoothened (Smo), a protein with high homology to the G-protein coupled receptors [6].

Analytical, diagnostic and therapeutic context of Smo

  • It is interesting that northern blot analysis with probes derived from the mouse Ptc and Smo genes revealed the expression of a 7.9-kb and a 3.7-kb transcript, respectively, in all brain tissues examined [3].


  1. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Sakurada, K., Ohshima-Sakurada, M., Palmer, T.D., Gage, F.H. Development (1999) [Pubmed]
  2. Sonic hedgehog and BMP2 exert opposing actions on proliferation and differentiation of embryonic neural progenitor cells. Zhu, G., Mehler, M.F., Zhao, J., Yu Yung, S., Kessler, J.A. Dev. Biol. (1999) [Pubmed]
  3. Regional distribution of Sonic Hedgehog, patched, and smoothened mRNA in the adult rat brain. Traiffort, E., Charytoniuk, D.A., Faure, H., Ruat, M. J. Neurochem. (1998) [Pubmed]
  4. Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system. Traiffort, E., Charytoniuk, D., Watroba, L., Faure, H., Sales, N., Ruat, M. Eur. J. Neurosci. (1999) [Pubmed]
  5. Sonic Hedgehog signalling in the developing and adult brain. Charytoniuk, D., Porcel, B., Rodríguez Gomez, J., Faure, H., Ruat, M., Traiffort, E. J. Physiol. Paris (2002) [Pubmed]
  6. Intrastriatal sonic hedgehog injection increases Patched transcript levels in the adult rat subventricular zone. Charytoniuk, D., Traiffort, E., Hantraye, P., Hermel, J.M., Galdes, A., Ruat, M. Eur. J. Neurosci. (2002) [Pubmed]
WikiGenes - Universities