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Smo  -  smoothened, frizzled class receptor

Rattus norvegicus

Synonyms: SMO, Smoh, Smoothened homolog
 
 
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High impact information on Smo

  • Adult rat-derived hippocampal progenitor cells express many of the molecules implicated in midbrain dopaminergic determination, including FGF receptors 1, 2 and 3, the sonic hedgehog receptor components Smo and Ptc, and the region-specific transcription factors Ptx3 and Nurr1 [1].
  • Transcripts for the putative Shh-receptor genes patched (Ptc) and smoothened (Smo) are expressed by embryonic, postnatal, and adult progenitor cells, suggesting that Shh can act directly on these cells [2].
  • In situ hybridization experiments using specific digoxigenin-labeled riboprobes showed expression of Ptc and Smo transcripts in discrete brain areas [3].
  • Interestingly, Smo transcripts were predominantly present within circumventricular organs, in granular cells of the dentate gyrus and in neurons of the reticular thalamic nucleus [4].
  • We have performed a detailed localization of cells expressing transcripts of Shh, Ptc, Smo and Gli1 in brain and spinal cord of the adult rat as well as in the developing cerebellum [4].
 

Anatomical context of Smo

 

Physical interactions of Smo

  • These observations suggest that in the adult brain, Shh signals through its receptor complex Ptc/Smo, or through Ptc alone [5].
 

Other interactions of Smo

  • This receptor for Shh is associated with Smoothened (Smo), a protein with high homology to the G-protein coupled receptors [6].
 

Analytical, diagnostic and therapeutic context of Smo

  • It is interesting that northern blot analysis with probes derived from the mouse Ptc and Smo genes revealed the expression of a 7.9-kb and a 3.7-kb transcript, respectively, in all brain tissues examined [3].

References

  1. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Sakurada, K., Ohshima-Sakurada, M., Palmer, T.D., Gage, F.H. Development (1999) [Pubmed]
  2. Sonic hedgehog and BMP2 exert opposing actions on proliferation and differentiation of embryonic neural progenitor cells. Zhu, G., Mehler, M.F., Zhao, J., Yu Yung, S., Kessler, J.A. Dev. Biol. (1999) [Pubmed]
  3. Regional distribution of Sonic Hedgehog, patched, and smoothened mRNA in the adult rat brain. Traiffort, E., Charytoniuk, D.A., Faure, H., Ruat, M. J. Neurochem. (1998) [Pubmed]
  4. Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system. Traiffort, E., Charytoniuk, D., Watroba, L., Faure, H., Sales, N., Ruat, M. Eur. J. Neurosci. (1999) [Pubmed]
  5. Sonic Hedgehog signalling in the developing and adult brain. Charytoniuk, D., Porcel, B., Rodríguez Gomez, J., Faure, H., Ruat, M., Traiffort, E. J. Physiol. Paris (2002) [Pubmed]
  6. Intrastriatal sonic hedgehog injection increases Patched transcript levels in the adult rat subventricular zone. Charytoniuk, D., Traiffort, E., Hantraye, P., Hermel, J.M., Galdes, A., Ruat, M. Eur. J. Neurosci. (2002) [Pubmed]
 
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