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Gene Review:

GFRA1 - GDNF family receptor alpha 1

Gallus gallus

Rothermel, A. et al., Schiltz, C.A. et al., Scott, R.P. et al., Karlsson, M. et al.

Rothermel, Volpert, Schlichting, Huhn, Stotz-Reimers, Robitzki, Layer,

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High impact information on GFRA1

All four GDNF family ligands utilize c-Ret as a common signaling receptor, whereas specificity is conferred by differential binding to four distinct GFRalpha homologues [1].
In the adult, GFRalpha1 and Ret were found in the neuropil of enteric ganglia [2].
GDNF family receptor alpha (GFRalpha) receptors are involved in the regulation of different aspects of embryonic development such as proliferation, migration, differentiation and survival [3].

Anatomical context of GFRA1

Expression of the GDNF receptors ret and GFRalpha1 in the developing avian enteric nervous system [2].

Other interactions of GFRA1

Overlapping and specific patterns of GDNF, c-ret and GFR alpha mRNA expression in the developing chicken retina [4].

References

Determinants of ligand binding specificity in the glial cell line-derived neurotrophic factor family receptor alpha S. Scott, R.P., Ibanez, C.F. J. Biol. Chem. (2001) [Pubmed]
Expression of the GDNF receptors ret and GFRalpha1 in the developing avian enteric nervous system. Schiltz, C.A., Benjamin, J., Epstein, M.L. J. Comp. Neurol. (1999) [Pubmed]
Spatial and temporal expression patterns of GDNF family receptor alpha4 in the developing chicken retina. Rothermel, A., Volpert, K., Schlichting, R., Huhn, J., Stotz-Reimers, M., Robitzki, A.A., Layer, P.G. Gene Expr. Patterns (2004) [Pubmed]
Overlapping and specific patterns of GDNF, c-ret and GFR alpha mRNA expression in the developing chicken retina. Karlsson, M., Lindqvist, N., Mayordomo, R., Hallböök, F. Mech. Dev. (2002) [Pubmed]

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GFRA1	Bos taurus
GFRA1	Canis lupus familiaris
gfra1a	Danio rerio
gfra1b	Danio rerio
GFRA1	Homo sapiens
Gfra1	Mus musculus
GFRA1	Pan troglodytes
Gfra1	Rattus norvegicus
gfra1	Xenopus (Silurana) tropicalis

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