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Gene Review

TBP  -  TATA box binding protein

Gallus gallus

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High impact information on TBP

  • We found that T3 (10(-8) M) selectively stimulates transcription from rGH-TRE- and TREpal-, but not ME-TRE- and F2-TRE-, containing templates in which these TREs are linked in front of the rGH minimal promoter containing only the TATA box binding protein, but not any other proximal binding protein, sequence [1].
  • Comparative analysis of the PDCD2-TBP-PSMB1 region in vertebrates [2].

Biological context of TBP


Other interactions of TBP

  • In six tested species but the zebrafish, the PSMB1 gene mapped head-to-head or in the close vicinity to the TBP, but even in the zebrafish, all three genes were syntenic [2].

Analytical, diagnostic and therapeutic context of TBP

  • By Northern blot analysis, we found that two transcripts with about 2.1 kb (cTBP0) and 2.7 kb (cTBP1) were expressed in various chicken tissues, though only one type of the TBP transcript was reported in vertebrates [3].


  1. In vitro transcriptional studies of the roles of the thyroid hormone (T3) response elements and minimal promoters in T3-stimulated gene transcription. Suen, C.S., Yen, P.M., Chin, W.W. J. Biol. Chem. (1994) [Pubmed]
  2. Comparative analysis of the PDCD2-TBP-PSMB1 region in vertebrates. Trachtulec, Z., Vlcek, C., Mihola, O., Forejt, J. Gene (2004) [Pubmed]
  3. Two forms of avian(chicken) TATA-binding protein mRNA generated by alternative polyadenylation. Yamauchi, J., Sugita, A., Fujiwara, M., Suzuki, K., Matsumoto, H., Yamazaki, T., Ninomiya, Y., Ono, T., Hasegawa, T., Masushige, S., Muramatsu, M., Tamura, T., Kato, S. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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