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Gene Review:

ACTG2 - actin, gamma 2, smooth muscle, enteric

Gallus gallus

Kovacs, A.M. et al., Strzelecka-Goøaszewska, H. et al., Terashima, M. et al.

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High impact information on ACTG2

In general, the developmental appearance of the gamma-enteric mRNA parallels that observed for this protein in previous studies indicating that the developmental expression of smooth muscle gamma-actin is regulated, in part, by an increased content of mRNA in chicken visceral smooth muscle cells during myogenesis [1].
Nucleotide sequence elucidated from an apparent full length smooth muscle gamma-actin cDNA revealed that it contained 94 bp of 5' non-translated sequence, an open reading frame of 1131 bp, and 97 bp of 3' non-translated sequence [1].
In the present study, we obtained evidence that chicken non-muscle beta/gamma-actin, skeletal muscle alpha-actin and smooth-muscle gamma-actin were ADP ribosylated by the heterophil ADP-ribosyltransferase [2].

Associations of ACTG2 with chemical compounds

This difference correlates with the deletion in smooth muscle gamma-actin of one out of four NH2-terminal acidic residues typical of skeletal and smooth muscle alpha-actin isoforms, suggesting that this additional acidic residue in alpha-actins is involved in the weak binding of cations which is essential for polymerization [3].

Analytical, diagnostic and therapeutic context of ACTG2

Molecular cloning and expression of the chicken smooth muscle gamma-actin mRNA [1].

References

Molecular cloning and expression of the chicken smooth muscle gamma-actin mRNA. Kovacs, A.M., Zimmer, W.E. Cell Motil. Cytoskeleton (1993) [Pubmed]
ADP-ribosylation of actins by arginine-specific ADP-ribosyltransferase purified from chicken heterophils. Terashima, M., Mishima, K., Yamada, K., Tsuchiya, M., Wakutani, T., Shimoyama, M. Eur. J. Biochem. (1992) [Pubmed]
Biochemical and theoretical approach to localization of metal-ion-binding sites in the actin primary structure. Strzelecka-Goøaszewska, H., Boguta, G., Zmorzyński, S., Moraczewska, J. Eur. J. Biochem. (1989) [Pubmed]

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ACT12	Arabidopsis thaliana
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Os10g0510000	Oryza sativa Japonica Group
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acta2	Xenopus (Silurana) tropicalis

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