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Gene Review

Actg2  -  actin, gamma 2, smooth muscle, enteric

Mus musculus

Synonyms: ACTA3, Act-4, Act4, Acta3, Actin, gamma-enteric smooth muscle, ...
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High impact information on Actg2


Biological context of Actg2


Anatomical context of Actg2

  • As a first step toward unraveling the mechanisms underlying smooth muscle development and differentiation, we have examined the tissue-specific and developmental expression patterns of six constructs carrying portions of the murine SMGA gene linked to chloramphenicol acetyltransferase (CAT) in stable lines of transgenic mice [3].
  • At the nonpermissive temperature for SV40 large T-antigen, the both level of SMGA mRNA and the number of cells staining for this actin are significantly increased in the presence of progesterone, a process that is similar to the upregulation of SMGA in the myometrium late in pregnancy [6].

Regulatory relationships of Actg2


  1. Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin. Kumar, A., Crawford, K., Close, L., Madison, M., Lorenz, J., Doetschman, T., Pawlowski, S., Duffy, J., Neumann, J., Robbins, J., Boivin, G.P., O'Toole, B.A., Lessard, J.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Identification and developmental expression of a smooth-muscle gamma-actin in postmeiotic male germ cells of mice. Kim, E., Waters, S.H., Hake, L.E., Hecht, N.B. Mol. Cell. Biol. (1989) [Pubmed]
  3. Tissue and developmental specific expression of murine smooth muscle gamma-actin fusion genes in transgenic mice. Qian, J., Kumar, A., Szucsik, J.C., Lessard, J.L. Dev. Dyn. (1996) [Pubmed]
  4. The mouse smooth muscle gamma actin gene is on chromosome 6. Kim, E., Kwon, Y.K., Trasler, J.M., Kozak, C.A., Hecht, N.B. Somat. Cell Mol. Genet. (1990) [Pubmed]
  5. Urogenital tract expression of enhanced green fluorescent protein in transgenic mice driven by a smooth muscle gamma-actin promoter. Szucsik, J.C., Lewis, A.G., Marmer, D.J., Lessard, J.L. J. Urol. (2004) [Pubmed]
  6. Establishment and characterization of a conditionally immortalized smooth muscle/myometrial-like cell line. Qian, J., Hendrix, M., Larsen, W.J., Dorn, G.W., Lessard, J.L. Mol. Reprod. Dev. (1997) [Pubmed]
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