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Gene Review

IRF1  -  interferon regulatory factor 1

Sus scrofa

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High impact information on IRF1

  • In contrast, in the mesenteric lymph node (MLN), only expression of IRF1 and IFNG was significantly upregulated [1].
  • Immunohistochemical analysis showed colocalization of IRF1, TLR2, and SOD1 protein in macrophages and confirmed the RNA expression data [2].


  1. Identification of key immune mediators regulating T helper 1 responses in swine. Dawson, H.D., Royaee, A.R., Nishi, S., Kuhar, D., Schnitzlein, W.M., Zuckermann, F., Urban, J., Lunney, J.K. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  2. Oxidized low-density lipoprotein correlates positively with toll-like receptor 2 and interferon regulatory factor-1 and inversely with superoxide dismutase-1 expression: studies in hypercholesterolemic swine and THP-1 cells. Holvoet, P., Davey, P.C., De Keyzer, D., Doukouré, M., Deridder, E., Bochaton-Piallat, M.L., Gabbiani, G., Beaufort, E., Bishay, K., Andrieux, N., Benhabilès, N., Marguerie, G. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
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