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Gene Review:

SCARB1 - scavenger receptor class B, member 1

Sus scrofa

Hansen, G.H. et al., Balazs, Z. et al., Kim, J.G. et al., Panzenboeck, U. et al.

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High impact information on SCARB1

In conclusion, the apoA-I/ABCA1- and HDL/SR-BI-dependent pathways modulate polarized sterol mobilization at the BBB [1].
Scavenger receptor class B type I (SR-BI) in pig enterocytes: trafficking from the brush border to lipid droplets during fat absorption [2].
In addition, SR-BI expression in the enterocyte brush border has also been reported but its role in the small intestine remains unclear [2].
BACKGROUND: Scavenger receptor class B type I (SR-BI) is known to mediate cellular uptake of cholesterol from high density lipoprotein particles and is particularly abundant in liver and steroidogenic tissues [2].
Immunohistochemistry of porcine brain cryosections revealed SR-BI expression on brain capillary endothelial cells and presumably astrocytic endfeet [3].

Biological context of SCARB1

Molecular cloning and endometrial expression of porcine high density lipoprotein receptor SR-BI during the estrous cycle and early pregnancy [4].

Anatomical context of SCARB1

RESULTS: In the fasting state, SR-BI was mainly localised in the microvillar membrane and in apical invaginations/pits between adjacent microvilli [2].
In primary porcine brain capillary endothelial cells HDL-associated alpha TocH was taken up in 10-fold excess of HDL holoparticles, indicating efficient selective uptake, a pathway mediated by scavenger receptor class B, type I (SR-BI) [3].
SR-BI was present in caveolae of brain capillary endothelial cells and expressed almost exclusively at the apical membrane [3].

Associations of SCARB1 with chemical compounds

Disruption of caveolae with methyl-beta-cyclodextrin (CDX) resulted in (mis)sorting of SR-BI to the basolateral membrane [3].

Other interactions of SCARB1

During mass transfer studies using alpha TocH-enriched HDL, approximately 50% of cellular alpha TocH was recovered with the bulk of cellular caveolin-1 and SR-BI [3].

Analytical, diagnostic and therapeutic context of SCARB1

AIM AND METHODS: To gain insight into the possible function of pig SR-BI during uptake of dietary fat, its localisation in enterocytes was studied in the fasting state and during fat absorption by immunogold electron microscopy and subcellular fractionation [2].

References

ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells. Panzenboeck, U., Balazs, Z., Sovic, A., Hrzenjak, A., Levak-Frank, S., Wintersperger, A., Malle, E., Sattler, W. J. Biol. Chem. (2002) [Pubmed]
Scavenger receptor class B type I (SR-BI) in pig enterocytes: trafficking from the brush border to lipid droplets during fat absorption. Hansen, G.H., Niels-Christiansen, L.L., Immerdal, L., Danielsen, E.M. Gut (2003) [Pubmed]
Uptake and transport of high-density lipoprotein (HDL) and HDL-associated alpha-tocopherol by an in vitro blood-brain barrier model. Balazs, Z., Panzenboeck, U., Hammer, A., Sovic, A., Quehenberger, O., Malle, E., Sattler, W. J. Neurochem. (2004) [Pubmed]
Molecular cloning and endometrial expression of porcine high density lipoprotein receptor SR-BI during the estrous cycle and early pregnancy. Kim, J.G., Vallet, J.L., Nonneman, D., Christenson, R.K. Mol. Cell. Endocrinol. (2004) [Pubmed]

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