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Gene Review:

SP1 - Sp1 transcription factor

Sus scrofa

Brunelleschi, S. et al., Piercey, M.F. et al., Kim, S.A. et al., Schwerin, M. et al.

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High impact information on SP1

In supershift assay, potential regulatory elements in this region, SP1 and GATA-1, were not responsive to the inhibition of TSP-1 expression by PMA [1].
While fMLP exerted similar effects in both populations, dose-response curves for SP1 NKA and the NK2 receptor agonist were shifted leftwards (1, 4 and 3 orders of magnitude, respectively) in sensitized AMs [2].
DNA polymorphisms in two transcription control elements (SP1- and TATA-box) of porcine HSP70.2 gene detected by allele-specific PCR [3].
Stereospecificity of SP1 and SP2 substance P receptors [4].
In contrast, substitution of the same residue with D-Proline results in a potent and selective agonist for SP1 receptors [4].

References

Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells. Kim, S.A., Hong, K.J. Exp. Mol. Med. (2000) [Pubmed]
Modulation by protein kinase C of the enhanced responsiveness to tachykinins in ovalbumin-sensitized guinea pig alveolar macrophages. Brunelleschi, S., Guidotto, S., Tonso, E., Viano, I., Fantozzi, R. Neuropeptides (1996) [Pubmed]
DNA polymorphisms in two transcription control elements (SP1- and TATA-box) of porcine HSP70.2 gene detected by allele-specific PCR. Schwerin, M., von Lengerken, G., Fredholm, M., Christensen, K., Krause, S. Anim. Genet. (1995) [Pubmed]
Stereospecificity of SP1 and SP2 substance P receptors. Piercey, M.F., Dobry-Schreur, P.J., Masiques, N., Schroeder, L.A. Life Sci. (1985) [Pubmed]

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