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Gene Review:

PKR - double stranded RNA-dependent protein kinase

Sus scrofa

de Los Santos, T. et al., Langland, J.O. et al., Chinsangaram, J. et al., Rowland, R.R. et al., Asano, A. et al.

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Disease relevance of PKR

The porcine group C rotavirus (Cowden strain) NSP3 protein (the group C equivalent of the group A gene 7 product, formerly called NS34) shares homology with known double-stranded RNA-binding proteins, such as the interferon-induced, double-stranded RNA-dependent protein kinase PKR [1].
Inhibition of L-deleted foot-and-mouth disease virus replication by alpha/beta interferon involves double-stranded RNA-dependent protein kinase [2].

High impact information on PKR

Here we show that in addition to preventing IFN-alpha/beta protein synthesis, L(pro) reduces the level of immediate-early induction of IFN-beta mRNA and IFN-stimulated gene products such as double-stranded RNA-dependent protein kinase R (PKR), 2',5'-oligoadenylate synthetase, and Mx1 mRNAs in swine cells [3].

Biological context of PKR

Virus replication was partially restored by the addition of 2-aminopurine (2-AP), an inhibitor of dsRNA inducible protein kinase (PKR) [4].

Anatomical context of PKR

The treatment with IFN-alpha induced the expression of PKR 3.9-fold in a porcine kidney cell line, LLC-PK1 [5].

References

Products of the porcine group C rotavirus NSP3 gene bind specifically to double-stranded RNA and inhibit activation of the interferon-induced protein kinase PKR. Langland, J.O., Pettiford, S., Jiang, B., Jacobs, B.L. J. Virol. (1994) [Pubmed]
Inhibition of L-deleted foot-and-mouth disease virus replication by alpha/beta interferon involves double-stranded RNA-dependent protein kinase. Chinsangaram, J., Koster, M., Grubman, M.J. J. Virol. (2001) [Pubmed]
The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response. de Los Santos, T., de Avila Botton, S., Weiblen, R., Grubman, M.J. J. Virol. (2006) [Pubmed]
Inhibition of porcine reproductive and respiratory syndrome virus by interferon-gamma and recovery of virus replication with 2-aminopurine. Rowland, R.R., Robinson, B., Stefanick, J., Kim, T.S., Guanghua, L., Lawson, S.R., Benfield, D.A. Arch. Virol. (2001) [Pubmed]
The mRNA regulation of porcine double-stranded RNA-activated protein kinase gene. Asano, A., Kon, Y., Agui, T. J. Vet. Med. Sci. (2004) [Pubmed]

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