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Chemical Compound Review

Papapa     [(2R,3R,5R)-5-(6-aminopurin- 9-yl)-4-[[(2R...

Synonyms: Oligoadenylate, Oligo(A), KST-1A6679, AR-1A8129, LS-176156, ...
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Disease relevance of Oligoadenylate


Psychiatry related information on Oligoadenylate


High impact information on Oligoadenylate

  • Double-stranded RNA is critical to vaccine function because both the immunogenicity and the anti-tumor activity of the vaccine are blocked in mice deficient for the RNase L enzyme, a key component of the 2',5'-linked oligoadenylate synthetase antiviral pathway involved in double-stranded RNA recognition [8].
  • Furthermore, the enhanced antiviral effect of asialo-IFN-beta was supported by induction of the 2'-5' oligoadenylate synthetase, an indicator of IFN activity, at a level significantly higher than that produced by conventional IFN-beta [9].
  • A second has no introns but has a polyadenylate signal and an oligoadenylate tract at its 3' end, and it is flanked by a short direct repeat [10].
  • Activation of 2'-5' oligoadenylate synthetase gene expression may mediate certain antiproliferative and antiviral effects of interferons [11].
  • Similarly, the induction of 2',5'-oligoadenylate synthetase following IFN-gamma treatment was completely depressed in transformed cells [12].

Chemical compound and disease context of Oligoadenylate


Biological context of Oligoadenylate


Anatomical context of Oligoadenylate


Associations of Oligoadenylate with other chemical compounds


Gene context of Oligoadenylate


Analytical, diagnostic and therapeutic context of Oligoadenylate


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