Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

bmp1-b - bone morphogenetic protein 1

Xenopus laevis

Synonyms: bmp-1, bmp1b, tld, tolloid, xbmp1, ...

Maéno, M. et al., Scott, I.C. et al., Shimizu, K. et al., Goodman, S.A. et al.

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High impact information on BMP-1

Differences in enzymatic activities and expression domains of the four proteases suggest BMP-1 as the major Chordin antagonist in early mammalian embryogenesis and in pre- and postnatal skeletogenesis [1].
BMP1-related metalloproteinases promote the development of ventral mesoderm in early Xenopus embryos [2].
Three sizes of mRNA (2.9, 5.2 and 6.6 kb) were detected in blastula (st.9) and early gastrula (st.10) embryos, and in hatched tadpole (st.40), but little or no expression was observed in morula (st.7) and late gastrula (st.12) embryos, suggesting a physiological role(s) of X.laevis BMP-1 in normal embryonic development [3].
Isolation of connective-tissue-specific genes involved in Xenopus intestinal remodeling: thyroid hormone up-regulates Tolloid/BMP-1 expression [4].

References

Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. Scott, I.C., Blitz, I.L., Pappano, W.N., Imamura, Y., Clark, T.G., Steiglitz, B.M., Thomas, C.L., Maas, S.A., Takahara, K., Cho, K.W., Greenspan, D.S. Dev. Biol. (1999) [Pubmed]
BMP1-related metalloproteinases promote the development of ventral mesoderm in early Xenopus embryos. Goodman, S.A., Albano, R., Wardle, F.C., Matthews, G., Tannahill, D., Dale, L. Dev. Biol. (1998) [Pubmed]
Cloning and expression of cDNA encoding Xenopus laevis bone morphogenetic protein-1 during early embryonic development. Maéno, M., Xue, Y., Wood, T.I., Ong, R.C., Kung, H.F. Gene (1993) [Pubmed]
Isolation of connective-tissue-specific genes involved in Xenopus intestinal remodeling: thyroid hormone up-regulates Tolloid/BMP-1 expression. Shimizu, K., Ishizuya-Oka, A., Amano, T., Yoshizato, K., Ueda, S. Dev. Genes Evol. (2002) [Pubmed]

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