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smurf1  -  SMAD specific E3 ubiquitin protein ligase 1

Xenopus laevis

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High impact information on Smurf1

  • Herein, we examined whether Smurf1 negatively regulates BMP signaling together with the I-Smads Smad6/7 [1].
  • In addition, Smurf1 associates with transforming growth factor-beta type I receptor through the inhibitory Smad (I-Smad) Smad7 and induces their degradation [1].
  • We conclude that in Xenopus embryos, the BMP pathway is a major physiological target of Smurf1, and we propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm [2].
  • Smurf1 is enriched on the dorsal side of gastrula stage embryos, and blocking Smurf1 disturbs neural folding and neural, but not mesoderm differentiation, enhances BMP/Smad1 signaling, and elevates phospho-Smad1 levels in the dorsal ectoderm [2].
  • Our data also reveal a novel role for Smurf1 and Smad1 in neural plate morphogenesis [2].

Biological context of Smurf1


Other interactions of Smurf1


  1. Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. Murakami, G., Watabe, T., Takaoka, K., Miyazono, K., Imamura, T. Mol. Biol. Cell (2003) [Pubmed]
  2. Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway. Alexandrova, E.M., Thomsen, G.H. Dev. Biol. (2006) [Pubmed]
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