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Gene Review:

prfA - peptide chain release factor 1

Escherichia coli UTI89

Pedersen, L.B. et al., Kelly, S.J. et al.

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Disease relevance of prfA

The prfA genes of Bacillus stearothermophilus and Bacillus subtilis are in an operon downstream of the ponA gene encoding penicillin-binding protein 1 (PBP1), a major enzyme involved in peptidoglycan synthesis [1].

High impact information on prfA

Previous work has shown that the ponA gene, encoding penicillin-binding protein 1 (PBP1), is in a two-gene operon with prfA (PBP-related factor A) (also called recU), which encodes a putative 206-residue basic protein (pI = 10.1) with no significant sequence homology to proteins with known functions [2].
We now show that prfA mutant cells have a defect in chromosome segregation resulting in the production of approximately 0.9 to 3% anucleate cells in prfA cultures grown at 30 or 37 degrees C in rich medium and that the lack of PrfA exacerbates the chromosome segregation defect in smc and spoOJ mutant cells [2].

References

Structural characterization of penicillin-binding protein-related factor A (PrfA) from Bacillus species. Kelly, S.J., Stein, R.A., Bagyan, I., Setlow, P., Jedrzejas, M.J. J. Struct. Biol. (2000) [Pubmed]
Penicillin-binding protein-related factor A is required for proper chromosome segregation in Bacillus subtilis. Pedersen, L.B., Setlow, P. J. Bacteriol. (2000) [Pubmed]

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