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Gene Review

fzd1  -  frizzled class receptor 1

Xenopus laevis

Synonyms: Xfrizzled-1, frizzled1, frz-1, frz1, fzd1-A
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High impact information on fzd1-A


Biological context of fzd1-A


Anatomical context of fzd1-A

  • A role for frizzled 3 in neural crest development [7].
  • The recent discovery that Frizzled proteins are receptor for Wnts has been quickly followed by the identification of a secreted protein, Frzb, that is related to Frizzled, expressed by the Spemann organizer in frog embryos and can bind to and antagonize Wnt developmental signalling molecules [8].

Associations of fzd1-A with chemical compounds

  • An expression cloning screen was used to isolate a novel gene homologous to the extracellular cysteine-rich domain of frizzled receptors [9].
  • Since targets of this Ca(2+) release could play a role in Wnt signaling, we first tested the hypothesis that Ca(2+)/calmodulin-dependent protein kinase II (CamKII) is activated by some Wnt and Frizzled homologs [10].

Regulatory relationships of fzd1-A

  • Wnt proteins signal through seven-pass transmembrane receptors of the frizzled family to activate beta-catenin-dependent transcription of target genes [6].

Other interactions of fzd1-A

  • The maternal Xenopus beta-catenin signaling pathway, activated by frizzled homologs, induces goosecoid in a cell non-autonomous manner [11].
  • To assess the endogenous role of frizzled proteins during vertebrate development, we have identified and characterized a Xenopus frizzled gene (xfz8) [12].


  1. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Wang, S., Krinks, M., Lin, K., Luyten, F.P., Moos, M. Cell (1997) [Pubmed]
  2. PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements. Kinoshita, N., Iioka, H., Miyakoshi, A., Ueno, N. Genes Dev. (2003) [Pubmed]
  3. Rap2 is required for Wnt/beta-catenin signaling pathway in Xenopus early development. Choi, S.C., Han, J.K. EMBO J. (2005) [Pubmed]
  4. Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Wu, J., O'donnell, M., Gitler, A.D., Klein, P.S. Development (2006) [Pubmed]
  5. Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development. Tan, C., Deardorff, M.A., Saint-Jeannet, J.P., Yang, J., Arzoumanian, A., Klein, P.S. Development (2001) [Pubmed]
  6. Frizzled receptor dimerization is sufficient to activate the Wnt/beta-catenin pathway. Carron, C., Pascal, A., Djiane, A., Boucaut, J.C., Shi, D.L., Umbhauer, M. J. Cell. Sci. (2003) [Pubmed]
  7. A role for frizzled 3 in neural crest development. Deardorff, M.A., Tan, C., Saint-Jeannet, J.P., Klein, P.S. Development (2001) [Pubmed]
  8. Cell-cell signalling: frog frizbees. Zorn, A.M. Curr. Biol. (1997) [Pubmed]
  9. Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos. Salic, A.N., Kroll, K.L., Evans, L.M., Kirschner, M.W. Development (1997) [Pubmed]
  10. Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. Kühl, M., Sheldahl, L.C., Malbon, C.C., Moon, R.T. J. Biol. Chem. (2000) [Pubmed]
  11. The maternal Xenopus beta-catenin signaling pathway, activated by frizzled homologs, induces goosecoid in a cell non-autonomous manner. Brown, J.D., Hallagan, S.E., McGrew, L.L., Miller, J.R., Moon, R.T. Dev. Growth Differ. (2000) [Pubmed]
  12. Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis. Deardorff, M.A., Tan, C., Conrad, L.J., Klein, P.S. Development (1998) [Pubmed]
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