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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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aer  -  aerotaxis sensor receptor, flavoprotein

Escherichia coli UTI89

 
 
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Disease relevance of aer

  • To investigate properties of the PAS domain, we subcloned segments of the aer gene from E. coli that encode the PAS domain with and without His6 tags and expressed the PAS peptides in E. coli [1].
 

High impact information on aer

  • We then introduced either an aer or tsr mutation into each mutant to create two sets of electron transport mutants [2].
  • Over half of the drb-positive strains and 80% of those positive for afaE5 have the same virulence signature (positive for aer, kpsMT, ompT, and fim), suggesting an association of this profile with UTI pathogenesis [3].
  • For this purpose, 77 strains of E. coli were genetically characterized by exploring their entire genomes by random amplified polymorphism of DNA (RAPD), and by determining their phylogenetic position in ECOR (E. coli reference) groups, the virulence factors harboured (pap, sfa, afa, hly, aer and cnf) and their ability to mutate [4].
 

Analytical, diagnostic and therapeutic context of aer

  • The primers used in the PCR targeted a 209-bp fragment of the aer gene coding for the beta-haemolysin and detected template DNA only in haemolytic A. hydrophila strains [5].

References

  1. PAS domain of the Aer redox sensor requires C-terminal residues for native-fold formation and flavin adenine dinucleotide binding. Herrmann, S., Ma, Q., Johnson, M.S., Repik, A.V., Taylor, B.L. J. Bacteriol. (2004) [Pubmed]
  2. Differentiation between electron transport sensing and proton motive force sensing by the Aer and Tsr receptors for aerotaxis. Edwards, J.C., Johnson, M.S., Taylor, B.L. Mol. Microbiol. (2006) [Pubmed]
  3. Distribution of drb genes coding for Dr binding adhesins among uropathogenic and fecal Escherichia coli isolates and identification of new subtypes. Zhang, L., Foxman, B., Tallman, P., Cladera, E., Le Bouguenec, C., Marrs, C.F. Infect. Immun. (1997) [Pubmed]
  4. Genetic relationship between Escherichia coli strains isolated from the intestinal flora and those responsible for infectious diseases among patients hospitalized in intensive care units. Mereghetti, L., Tayoro, J., Watt, S., Lanotte, P., Loulergue, J., Perrotin, D., Quentin, R. J. Hosp. Infect. (2002) [Pubmed]
  5. Detection of aerolysin gene in Aeromonas strains isolated from drinking water, fish and foods by the polymerase chain reaction. Baloda, S.B., Krovacek, K., Eriksson, L., Linné, T., Månsson, I. Comp. Immunol. Microbiol. Infect. Dis. (1995) [Pubmed]
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