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Gene Review:

fzd8-b - frizzled class receptor 8

Xenopus laevis

Synonyms: FZD8, Fz-8, frizzled8, xfz8

Deardorff, M.A. et al., Itoh, K. et al.

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High impact information on xfz8

Our results suggest a role for xfz8 in morphogenesis during the gastrula stage of embryogenesis [1].
To assess the endogenous role of frizzled proteins during vertebrate development, we have identified and characterized a Xenopus frizzled gene (xfz8) [1].
Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis [1].
Reorganization of actin cytoskeleton by FRIED, a Frizzled-8 associated protein tyrosine phosphatase [2].

References

Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis. Deardorff, M.A., Tan, C., Conrad, L.J., Klein, P.S. Development (1998) [Pubmed]
Reorganization of actin cytoskeleton by FRIED, a Frizzled-8 associated protein tyrosine phosphatase. Itoh, K., Lisovsky, M., Hikasa, H., Sokol, S.Y. Dev. Dyn. (2005) [Pubmed]

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