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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cyp17a1  -  cytochrome P450, family 17, subfamily A,...

Danio rerio

Synonyms: P450c17, SO:0000704, cyp17, wu:fi13g04, wu:fi17b11, ...
 
 
 
 
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High impact information on cyp17a1

  • We further examined the expression of P450c17 in the developing ovarian follicles [1].
  • Northern blot analysis demonstrated that it is predominantly expressed in the ovary and testis; however, a weak hybridization signal was also detected in the whole kidney of the zebrafish, suggesting a role for P450c17 in the steroidogenesis of both gonads and renal/interrenal tissues [1].
 

Analytical, diagnostic and therapeutic context of cyp17a1

  • It is also of interest to note that when assayed by RT-PCR, the enzyme P450c17 also seemed to be expressed in several other non-gonadal tissues including the brain, gill, liver and intestine, and its expression did not show significant sexual dimorphism in the brain of adult zebrafish [1].

References

  1. Cloning of zebrafish ovarian P450c17 (CYP17, 17alpha-hydroxylase/17, 20-lyase) and characterization of its expression in gonadal and extra-gonadal tissues. Wang, Y., Ge, W. Gen. Comp. Endocrinol. (2004) [Pubmed]
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