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MeSH Review

Ovarian Follicle

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Disease relevance of Ovarian Follicle


High impact information on Ovarian Follicle


Chemical compound and disease context of Ovarian Follicle


Biological context of Ovarian Follicle


Anatomical context of Ovarian Follicle


Associations of Ovarian Follicle with chemical compounds

  • The alterations in morphology and function of the ovarian follicle as it matures, ovulates, and becomes a corpus luteum are dramatic [25].
  • C/EBP beta is thus established as a critical downstream target of G-protein-coupled LH receptor signaling and one of the first transcription factors, other than steroid hormone receptors, known to be required for ovarian follicle development in vivo [26].
  • In addition, increasing evidence demonstrates that Ang II is a major factor in regulating the function of atretic follicles [27].
  • Progesterone concentration (mean +/- SEM; ng/ml) of FF was generally elevated in all preovulatory follicles (635 +/- 53) compared to immature or atretic follicles (230 +/- 64 and 76 +/- 17, respectively; P less than 0.05) [28].
  • Localization of angiotensin II receptors in ovarian follicles and the identification of angiotensin II in rat ovaries [29].

Gene context of Ovarian Follicle

  • Hsf2(-/-) females suffer from multiple fertility defects: the production of abnormal eggs, the reduction in ovarian follicle number and the presence of hemorrhagic cystic follicles are consistent with meiotic defects [30].
  • Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells [31].
  • The neurogenic locus brainiac cooperates with the Drosophila EGF receptor to establish the ovarian follicle and to determine its dorsal-ventral polarity [32].
  • The interaction between brn and DER is also required for at least two earlier follicle cell activities which are necessary to establish the ovarian follicle [32].
  • The daughterless gene functions together with Notch and Delta in the control of ovarian follicle development in Drosophila [33].

Analytical, diagnostic and therapeutic context of Ovarian Follicle


  1. DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development. Bedell, M.A., Brannan, C.I., Evans, E.P., Copeland, N.G., Jenkins, N.A., Donovan, P.J. Genes Dev. (1995) [Pubmed]
  2. Effects of metoclopramide-induced hyperprolactinemia during early follicular development on human ovarian function. Kauppila, A., Kirkinen, P., Orava, M., Vihko, R. J. Clin. Endocrinol. Metab. (1984) [Pubmed]
  3. Ovarian hyperstimulation syndrome: prediction by number and size of preovulatory ovarian follicles. Blankstein, J., Shalev, J., Saadon, T., Kukia, E.E., Rabinovici, J., Pariente, C., Lunenfeld, B., Serr, D.M., Mashiach, S. Fertil. Steril. (1987) [Pubmed]
  4. Expression of insulin-receptor substrate-1 and -2 in ovaries from women with insulin resistance and from controls. Wu, X., Sallinen, K., Anttila, L., Mäkinen, M., Luo, C., Pöllänen, P., Erkkola, R. Fertil. Steril. (2000) [Pubmed]
  5. Noninvasive diagnosis of resistant ovary syndrome by ultrasonography. Mehta, A.E., Matwijiw, I., Lyons, E.A., Faiman, C. Fertil. Steril. (1992) [Pubmed]
  6. The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Crisponi, L., Deiana, M., Loi, A., Chiappe, F., Uda, M., Amati, P., Bisceglia, L., Zelante, L., Nagaraja, R., Porcu, S., Ristaldi, M.S., Marzella, R., Rocchi, M., Nicolino, M., Lienhardt-Roussie, A., Nivelon, A., Verloes, A., Schlessinger, D., Gasparini, P., Bonneau, D., Cao, A., Pilia, G. Nat. Genet. (2001) [Pubmed]
  7. A tissue-specific transcription enhancer from the Drosophila yolk protein 1 gene. Garabedian, M.J., Shepherd, B.M., Wensink, P.C. Cell (1986) [Pubmed]
  8. Follicular plasminogen and plasminogen activator and the effect of plasmin on ovarian follicle wall. Beers, W.H. Cell (1975) [Pubmed]
  9. Prolactin inhibits oestrogen synthesis in the ovary. Dorrington, J., Gore-Langton, R.E. Nature (1981) [Pubmed]
  10. Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Freiman, R.N., Albright, S.R., Zheng, S., Sha, W.C., Hammer, R.E., Tjian, R. Science (2001) [Pubmed]
  11. Effects of sulpiride-induced hyperprolactinemia on human ovarian follicles during the late follicular phase. Sowa, M., Tsuji, K., Nakano, R. Fertil. Steril. (1986) [Pubmed]
  12. Ovarian cysts in users of Implanon(R) and Jadelle(R) subdermal contraceptive implants. Hidalgo, M.M., Lisondo, C., Juliato, C.T., Espejo-Arce, X., Monteiro, I., Bahamondes, L. Contraception. (2006) [Pubmed]
  13. Significance of atretic follicles as the site of androgen production in polycystic ovaries. Mori, T., Fujita, Y., Nihnobu, K., Aso, T., Sakamoto, Y., Nishimura, T. J. Endocrinol. Invest. (1982) [Pubmed]
  14. Inhibition of ovarian compensatory hypertrophy by the administration of methyl parathion in hemicastrated albino rats. Dhondup, P., Kaliwal, B.B. Reprod. Toxicol. (1997) [Pubmed]
  15. Mast cell histamine and ovarian follicular growth in the lizard Anolis carolinensis. Jones, R.E., Tokarz, R.R., Roth, J.J., Platt, J.E., Collins, A.C. J. Exp. Zool. (1975) [Pubmed]
  16. Role of brain insulin receptor in control of body weight and reproduction. Brüning, J.C., Gautam, D., Burks, D.J., Gillette, J., Schubert, M., Orban, P.C., Klein, R., Krone, W., Müller-Wieland, D., Kahn, C.R. Science (2000) [Pubmed]
  17. The k43 gene, required for chorion gene amplification and diploid cell chromosome replication, encodes the Drosophila homolog of yeast origin recognition complex subunit 2. Landis, G., Kelley, R., Spradling, A.C., Tower, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  18. Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. Yan, W., Ma, L., Stein, P., Pangas, S.A., Burns, K.H., Bai, Y., Schultz, R.M., Matzuk, M.M. Mol. Cell. Biol. (2005) [Pubmed]
  19. polyhomeotic is required for somatic cell proliferation and differentiation during ovarian follicle formation in Drosophila. Narbonne, K., Besse, F., Brissard-Zahraoui, J., Pret, A.M., Busson, D. Development (2004) [Pubmed]
  20. Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturation. Jamnongjit, M., Gill, A., Hammes, S.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  21. Cloning and expression of cDNA for anti-müllerian hormone. Picard, J.Y., Benarous, R., Guerrier, D., Josso, N., Kahn, A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  22. Regulation of gonadotropin gene expression by Mullerian inhibiting substance. Bédécarrats, G.Y., O'Neill, F.H., Norwitz, E.R., Kaiser, U.B., Teixeira, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  23. N-cadherin-mediated human granulosa cell adhesion prevents apoptosis: a role in follicular atresia and luteolysis? Makrigiannakis, A., Coukos, G., Christofidou-Solomidou, M., Gour, B.J., Radice, G.L., Blaschuk, O., Coutifaris, C. Am. J. Pathol. (1999) [Pubmed]
  24. Deposition of immune complexes in ovarian follicles of mice with lupus-like syndrome. Accinni, L., Albini, B., Andres, G., Dixon, F.J. Am. J. Pathol. (1980) [Pubmed]
  25. Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle. Woodruff, T.K., D'Agostino, J., Schwartz, N.B., Mayo, K.E. Science (1988) [Pubmed]
  26. An essential role for C/EBPbeta in female reproduction. Sterneck, E., Tessarollo, L., Johnson, P.F. Genes Dev. (1997) [Pubmed]
  27. The ovarian renin-angiotensin system in reproductive physiology. Yoshimura, Y. Frontiers in neuroendocrinology. (1997) [Pubmed]
  28. Decline of follicular oocyte maturation inhibitor coincident with maturation and achievement of fertilizability of oocytes recovered at midcycle of gonadotropin-treated women. Channing, C.P., Liu, C.Q., Jones, G.S., Jones, H. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  29. Localization of angiotensin II receptors in ovarian follicles and the identification of angiotensin II in rat ovaries. Husain, A., Bumpus, F.M., De Silva, P., Speth, R.C. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  30. Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice. Kallio, M., Chang, Y., Manuel, M., Alastalo, T.P., Rallu, M., Gitton, Y., Pirkkala, L., Loones, M.T., Paslaru, L., Larney, S., Hiard, S., Morange, M., Sistonen, L., Mezger, V. EMBO J. (2002) [Pubmed]
  31. Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. Cayirlioglu, P., Ward, W.O., Silver Key, S.C., Duronio, R.J. Mol. Cell. Biol. (2003) [Pubmed]
  32. The neurogenic locus brainiac cooperates with the Drosophila EGF receptor to establish the ovarian follicle and to determine its dorsal-ventral polarity. Goode, S., Wright, D., Mahowald, A.P. Development (1992) [Pubmed]
  33. The daughterless gene functions together with Notch and Delta in the control of ovarian follicle development in Drosophila. Cummings, C.A., Cronmiller, C. Development (1994) [Pubmed]
  34. Clusterin protects granulosa cells from apoptotic cell death during follicular atresia. Zwain, I., Amato, P. Exp. Cell Res. (2000) [Pubmed]
  35. Flow cytometric deoxyribonucleic acid analysis of granulosa cells aspirated from human ovarian follicles. A new method to distinguish healthy and atretic ovarian follicles. Westergaard, L., McNatty, K.P., Christensen, I., Larsen, J.K., Byskov, A.G. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  36. Unilateral ovariectomy increases inhibin messenger ribonucleic acid levels in newly recruited follicles. D'Agostino, J., Woodruff, T.K., Mayo, K.E., Schwartz, N.B. Endocrinology (1989) [Pubmed]
  37. Phosphorylation of mitochondrial proteins in isolated porcine ovarian follicles after treatment with luteinizing hormone. Neymark, M.A., Bieszczad, R.R., Dimino, M.J. Endocrinology (1984) [Pubmed]
  38. Cloning of transforming growth factor-beta 1 (TGF-beta 1) and its type II receptor from zebrafish ovary and role of TGF-beta 1 in oocyte maturation. Kohli, G., Hu, S., Clelland, E., Di Muccio, T., Rothenstein, J., Peng, C. Endocrinology (2003) [Pubmed]
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