Disease relevance of Eip78C

• We have generated a number of chromosomal aberrations that disrupt the early-late ecdysone-induced 78C puff gene (Eip78C, ecdysone-induced protein, FlyBase name for the E78 gene of Stone and Thummel 1993), which encodes the two members of the nuclear hormone receptor superfamily Eip78C-A and Eip78C-B [1].

High impact information on Eip78C

• The Drosophila 78C early late puff contains E78, an ecdysone-inducible gene that encodes a novel member of the nuclear hormone receptor superfamily [2].
• E78B encodes a truncated receptor isoform that lacks the DNA-binding domain and is predominantly expressed at puparium formation and immediately following E78A in pupae [2].
• With the exception of E78A, which did not bind any sequence tested, each of the remaining proteins is able to bind to a single consensus AGGTCA half-site; however, each displayed different specificities depending on the flanking nucleotide sequence [3].
• The Drosophila Eip78C gene is not vital but has a role in regulating chromosome puffs [1].
• DR-78, a novel Drosophila melanogaster genomic DNA fragment highly homologous to the DNA-binding domain of thyroid hormone-retinoic acid-vitamin D receptor subfamily [4].

Biological context of Eip78C

• Genomic lambda DASH clones were identified at high stringency with an amplified DR-78 plasmid DNA and isolated [4].

References