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Gene Review:

BDNF - brain-derived neurotrophic factor

Canis lupus familiaris

Takeda, K. et al., Ruggieri, M.R. et al., Head, E. et al.

Ruggieri, Braverman, D'Andrea, Simpkiss, Kozin, Pontari, Betz, Barbe, Head, Thornton, Tong, Cotman,

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High impact information on BDNF

At 6-12 months post-surgery, five of eight nerve transected and repaired animals showed increased pressure and bladder emptying during electrical stimulation of the repaired ventral roots contralateral to the BDNF delivery side [1].
These findings suggest that the regulation of functioning of periodontal ligament cells and endothelial cells by BDNF results in the promotion of periodontal tissue regeneration [2].
In vivo studies showed that BDNF stimulated the formation of new alveolar bone cementum and connective new fibers, which were inserted into the newly formed cementum and bone [2].
CREB phosphorylation is associated with the expression of brain derived neurotrophic factor (BDNF), which promotes neuron health and survival [3].

References

Functional reinnervation of the canine bladder after spinal root transection and immediate end-on-end repair. Ruggieri, M.R., Braverman, A.S., D'Andrea, L., Simpkiss, B., Kozin, S.H., Pontari, M.A., Betz, R., Barbe, M.F. J. Neurotrauma (2006) [Pubmed]
Brain-derived neurotrophic factor enhances periodontal tissue regeneration. Takeda, K., Shiba, H., Mizuno, N., Hasegawa, N., Mouri, Y., Hirachi, A., Yoshino, H., Kawaguchi, H., Kurihara, H. Tissue engineering. (2005) [Pubmed]
Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging. Head, E., Thornton, P.L., Tong, L., Cotman, C.W. Prog. Neuropsychopharmacol. Biol. Psychiatry (2000) [Pubmed]

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BDNF	Bos taurus
bdnf	Danio rerio
BDNF	Gallus gallus
BDNF	Homo sapiens
BDNF	Macaca mulatta
Bdnf	Mus musculus
BDNF	Pan troglodytes
Bdnf	Rattus norvegicus
bdnf	Xenopus (Silurana) tropicalis

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