Gene Review:
Bdnf - brain derived neurotrophic factor
Mus musculus
Synonyms:
BDNF, Brain-derived neurotrophic factor
- Stroke damage in mice after knocking the neutrophin-4 gene into the brain-derived neurotrophic factor locus. Endres, M., Fan, G., Hirt, L., Jaenisch, R. J. Cereb. Blood Flow Metab. (2003)
- Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 complement and cooperate with each other sequentially during visceral neuron development. ElShamy, W.M., Ernfors, P. J. Neurosci. (1997)
- Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice. Pang, T.Y., Stam, N.C., Nithianantharajah, J., Howard, M.L., Hannan, A.J. Neuroscience (2006)
- Site-specific interactions of neurotrophin-3 and fibroblast growth factor (FGF2) in the embryonic development of the mouse cochlear nucleus. Hossain, W.A., D'Sa, C., Morest, D.K. J. Neurobiol. (2006)
- Brain-derived neurotrophic factor facilitates in vivo internalization of tetanus neurotoxin C-terminal fragment fusion proteins in mature mouse motor nerve terminals. Roux, S., Saint Cloment, C., Curie, T., Girard, E., Mena, F.J., Barbier, J., Osta, R., Molg??, J., Br??let, P. Eur. J. Neurosci. (2006)
- BDNF heterozygous mice demonstrate age-related changes in striatal and nigral gene expression. Saylor, A.J., Meredith, G.E., Vercillo, M.S., Zahm, D.S., McGinty, J.F. Exp. Neurol. (2006)
- BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Huang, Z.J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M.F., Maffei, L., Tonegawa, S. Cell (1999)
- Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Nakagawa, T., Tsuchida, A., Itakura, Y., Nonomura, T., Ono, M., Hirota, F., Inoue, T., Nakayama, C., Taiji, M., Noguchi, H. Diabetes (2000)
- BDNF regulates the expression of fragile X mental retardation protein mRNA in the hippocampus. Castrén, M., Lampinen, K.E., Miettinen, R., Koponen, E., Sipola, I., Bakker, C.E., Oostra, B.A., Castrén, E. Neurobiol. Dis. (2002)
- Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Liu, Q.R., Lu, L., Zhu, X.G., Gong, J.P., Shaham, Y., Uhl, G.R. Brain. Res. (2006)
- Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Gauthier, L.R., Charrin, B.C., Borrell-Pagès, M., Dompierre, J.P., Rangone, H., Cordelières, F.P., De Mey, J., MacDonald, M.E., Lessmann, V., Humbert, S., Saudou, F. Cell (2004)
- Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Jones, K.R., Fariñas, I., Backus, C., Reichardt, L.F. Cell (1994)
- Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Klein, R., Smeyne, R.J., Wurst, W., Long, L.K., Auerbach, B.A., Joyner, A.L., Barbacid, M. Cell (1993)
- Running is the neurogenic and neurotrophic stimulus in environmental enrichment. Kobilo, T., Liu, Q.R., Gandhi, K., Mughal, M., Shaham, Y., van Praag, H. Learn. Mem. (2011)
- The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice. Aharoni, R., Eilam, R., Domev, H., Labunskay, G., Sela, M., Arnon, R. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice. Tonra, J.R., Ono, M., Liu, X., Garcia, K., Jackson, C., Yancopoulos, G.D., Wiegand, S.J., Wong, V. Diabetes (1999)
- Direct evidence for the involvement of brain-derived neurotrophic factor in the development of a neuropathic pain-like state in mice. Yajima, Y., Narita, M., Usui, A., Kaneko, C., Miyatake, M., Narita, M., Yamaguchi, T., Tamaki, H., Wachi, H., Seyama, Y., Suzuki, T. J. Neurochem. (2005)
- Neuroprotection of immortalized hippocampal neurones by brain-derived neurotrophic factor and Raf-1 protein kinase: role of extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase. Rössler, O.G., Giehl, K.M., Thiel, G. J. Neurochem. (2004)
- Correlated long-term increase of brain-derived neurotrophic factor and Trk B proteins in enlarged granule cells of mouse hippocampus after kainic acid injection. Inoue, T., Hirai, H., Onteniente, B., Suzuki, F. Neuroscience (1998)
- The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Klein, R., Nanduri, V., Jing, S.A., Lamballe, F., Tapley, P., Bryant, S., Cordon-Cardo, C., Jones, K.R., Reichardt, L.F., Barbacid, M. Cell (1991)
- Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. Conover, J.C., Erickson, J.T., Katz, D.M., Bianchi, L.M., Poueymirou, W.T., McClain, J., Pan, L., Helgren, M., Ip, N.Y., Boland, P. Nature (1995)
- Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia. Qiao, X., Hefti, F., Knusel, B., Noebels, J.L. J. Neurosci. (1996)
- Cerebellar brain-derived neurotrophic factor-TrkB defect associated with impairment of eyeblink conditioning in Stargazer mutant mice. Qiao, X., Chen, L., Gao, H., Bao, S., Hefti, F., Thompson, R.F., Knusel, B. J. Neurosci. (1998)
- A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control. Botchkarev, V.A., Botchkareva, N.V., Welker, P., Metz, M., Lewin, G.R., Subramaniam, A., Bulfone-Paus, S., Hagen, E., Braun, A., Lommatzsch, M., Renz, H., Paus, A.R. FASEB J. (1999)
- Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells. Verga??o-Vera, E., Yusta-Boyo, M.J., de Castro, F., Bernad, A., de Pablo, F., Vicario-Abej??n, C. Development (2006)
- Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention. Fritzsch, B., Matei, V.A., Nichols, D.H., Bermingham, N., Jones, K., Beisel, K.W., Wang, V.Y. Dev. Dyn. (2005)
- A disorganized innervation of the inner ear persists in the absence of ErbB2. Morris, J.K., Maklad, A., Hansen, L.A., Feng, F., Sorensen, C., Lee, K.F., Macklin, W.B., Fritzsch, B. Brain Res. (2006)
- BDNF but not NT-4 is required for normal flexion reflex plasticity and function. Heppenstall, P.A., Lewin, G.R. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Brain-derived neurotrophic factor regulates the expression of D1 dopamine receptors. Do, T., Kerr, B., Kuzhikandathil, E.V. J. Neurochem. (2007)
- Brain-derived neurotrophic factor attenuates mouse cerebellar granule cell GABA(A) receptor-mediated responses via postsynaptic mechanisms. Cheng, Q., Yeh, H.H. J. Physiol. (Lond.) (2003)
- Brain-derived neurotrophic factor is present in adult mouse taste cells with synapses. Yee, C.L., Jones, K.R., Finger, T.E. J. Comp. Neurol. (2003)
- c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation. Palmada, M., Kanwal, S., Rutkoski, N.J., Gustafson-Brown, C., Johnson, R.S., Wisdom, R., Carter, B.D., Gufstafson-Brown, C. J. Cell Biol. (2002)
- TrkB mutant lacking the amino-terminal half of the extracellular portion acts as a functional brain-derived neurotrophic factor receptor. Kojima, S., Nakayama, T., Kuwajima, G., Suzuki, H., Sakata, T. Biochim. Biophys. Acta (1999)
- Brain-derived neurotrophic factor stimulates phosphorylation of stathmin in cortical neurons. Cardinaux, J.R., Magistretti, P.J., Martin, J.L. Brain Res. Mol. Brain Res. (1997)
- Evidence that brain-derived neurotrophic factor from presynaptic nerve terminals regulates the phenotype of calbindin-containing neurons in the lateral septum. Fawcett, J.P., Alonso-Vanegas, M.A., Morris, S.J., Miller, F.D., Sadikot, A.F., Murphy, R.A. J. Neurosci. (2000)
- Differential influence of BDNF and NT3 on the expression of calcium binding proteins and neuropeptide Y in vivo. Agerman, K., Ernfors, P. Neuroreport (2003)
- NR2A but not NR2B N-methyl-D-aspartate receptor subunit is altered in the visual cortex of BDNF-knock-out mice. Margottil, E., Domenici, L. Cell. Mol. Neurobiol. (2003)
- Interaction of NT-4 and BDNF with gp145trkb receptor: effect on cellular metabolism. Hopkins, M.A., Rosser, M.P., Fernandes, P.B., Bursuker, I. J. Neurosci. Methods (1997)
- BDNF stimulates expression, activity and release of tissue-type plasminogen activator in mouse cortical neurons. Fiumelli, H., Jabaudon, D., Magistretti, P.J., Martin, J.L. Eur. J. Neurosci. (1999)
- TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor. Glass, D.J., Nye, S.H., Hantzopoulos, P., Macchi, M.J., Squinto, S.P., Goldfarb, M., Yancopoulos, G.D. Cell (1991)
- Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. Liebl, D.J., Tessarollo, L., Palko, M.E., Parada, L.F. J. Neurosci. (1997)
- Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons. Schecterson, L.C., Bothwell, M. Neuron (1992)
- Brain-derived neurotrophic factor levels in the nervous system of wild-type and neurotrophin gene mutant mice. Kolbeck, R., Bartke, I., Eberle, W., Barde, Y.A. J. Neurochem. (1999)