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Gene Review

BDNF  -  brain-derived neurotrophic factor

Pan troglodytes

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High impact information on BDNF

  • Similar responses were elicited by BDNF, although the sensitivity of each cell line was different than that found for NGF [1].
  • We evaluated also the role of NGF, BDNF and NT3 in the modulation of cell migration and invasion and, finally, the effects of a pan Trk inhibitor, CEP-701 which has been included in some clinical trials for the treatment of PCa [2].


  1. Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro. Zhang, J., Geula, C., Lu, C., Koziel, H., Hatcher, L.M., Roisen, F.J. Exp. Neurol. (2003) [Pubmed]
  2. Tyrosine kinase inhibitor CEP-701 blocks the NTRK1/NGF receptor and limits the invasive capability of prostate cancer cells in vitro. Festuccia, C., Muzi, P., Gravina, G.L., Millimaggi, D., Speca, S., Dolo, V., Ricevuto, E., Vicentini, C., Bologna, M. Int. J. Oncol. (2007) [Pubmed]
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