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Gene Review

TIMP2  -  TIMP metallopeptidase inhibitor 2

Canis lupus familiaris

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High impact information on TIMP2

  • Vein graft extracts were analyzed for MMPs, TIMP-2, tumor necrosis factor-alpha (TNF-alpha), polymorphonuclear neutrophil (PMN) infiltration, myeloperoxidase (MPO), and thrombin activity, and for ERK-1/2 activation [1].
  • After 1, 3, 6, and 12 days, glycosaminoglycan (GAG) concentrations in 3-D constructs; nitric oxide and prostaglandin E2 (PGE2) concentrations in media samples; and relative expressions of selected genes, including metalloproteinase (MMP)-13 and tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2, were evaluated [2].
  • Reverse zymography was used to detect TIMP-1 and TIMP-2 and all three cell lines produced both proteins [3].
  • The concentration of TIMP-2 in the synovial fluid of osteoarthritic dogs (46.2 +/- 21.9 ng/ml) was significantly less than that of control dogs (122.0 +/- 66.5 ng/ml) (P = 0.009) [4].


  1. Matrix metalloproteinase expression in vein grafts: role of inflammatory mediators and extracellular signal-regulated kinases-1 and -2. Sharony, R., Pintucci, G., Saunders, P.C., Grossi, E.A., Baumann, F.G., Galloway, A.C., Mignatti, P. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  2. Effects of proinflammatory cytokines on canine articular chondrocytes in a three-dimensional culture. Kuroki, K., Stoker, A.M., Cook, J.L. Am. J. Vet. Res. (2005) [Pubmed]
  3. Immunological and inflammatory characterisation of three canine cell lines: K1, K6 and DH82. Barnes, A., Bee, A., Bell, S., Gilmore, W., Mee, A., Morris, R., Carter, S.D. Vet. Immunol. Immunopathol. (2000) [Pubmed]
  4. Matrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and synovial fluid of osteoarthritic dogs. Salinardi, B.J., Roush, J.K., Schermerhorn, T., Mitchell, K.E. Veterinary and comparative orthopaedics and traumatology : V.C.O.T. (2006) [Pubmed]
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