Gene Review:
Timp2 - TIMP metallopeptidase inhibitor 2
Rattus norvegicus
Synonyms:
Metalloproteinase inhibitor 2, TIMP-2, Timp-2, Tissue inhibitor of metalloproteinases 2
- Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats. Hu, Y.B., Li, D.G., Lu, H.M. The journal of gene medicine (2007)
- Effects of benazepril on renal function and kidney expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in diabetic rats. Sun, S.Z., Wang, Y., Li, Q., Tian, Y.J., Liu, M.H., Yu, Y.H. Chin. Med. J. (2006)
- Long-term overexpression of membrane type-1 matrix metalloproteinase and matrix metalloproteinase-2 in oleic acid-induced pancreatitis in rats. Yamaguchi, T., Nakamura, H., Kihara, Y., Taguchi, M., Yoshikawa, H., Otsuki, M. Pancreas (2002)
- Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. Iredale, J.P., Benyon, R.C., Pickering, J., McCullen, M., Northrop, M., Pawley, S., Hovell, C., Arthur, M.J. J. Clin. Invest. (1998)
- Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros. Barasch, J., Yang, J., Qiao, J., Tempst, P., Erdjument-Bromage, H., Leung, W., Oliver, J.A. J. Clin. Invest. (1999)
- Plasminogen activator inhibitor type 1 and tissue inhibitor of metalloproteinases-2 increase after arterial injury in rats. Hasenstab, D., Forough, R., Clowes, A.W. Circ. Res. (1997)
- Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats. Bruck, R., Genina, O., Aeed, H., Alexiev, R., Nagler, A., Avni, Y., Pines, M. Hepatology (2001)
- Tissue inhibitor of metalloproteinase-2 (TIMP-2) expression is regulated by multiple neural differentiation signals. Jaworski, D.M., Pérez-Martínez, L. J. Neurochem. (2006)
- Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis. Arthur, M.J., Mann, D.A., Iredale, J.P. J. Gastroenterol. Hepatol. (1998)
- Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution. Manase, K., Endo, T., Chida, M., Nagasawa, K., Honnma, H., Yamazaki, K., Kitajima, Y., Goto, T., Kanaya, M., Hayashi, T., Mitaka, T., Saito, T. Reprod. Biol. Endocrinol. (2006)
- Expression of gelatinases A and B, and TIMPs 1 and 2 during corneal wound healing. Ye, H.Q., Azar, D.T. Invest. Ophthalmol. Vis. Sci. (1998)
- Cellular localization of tissue inhibitors of metalloproteinases in the rat ovary throughout pseudopregnancy. Curry, T.E., Wheeler, S.E. Biol. Reprod. (2002)
- Purification and sequence analysis of two rat tissue inhibitors of metalloproteinases. Roswit, W.T., McCourt, D.W., Partridge, N.C., Jeffrey, J.J. Arch. Biochem. Biophys. (1992)
- Angiotensin II-induced modulation of rat mesangial cell phenotype. Zhang, X., O'Malley, Y., Robbins, M.E. Radiat. Res. (1999)
- Cellular localization of gelatinases and tissue inhibitors of metalloproteinases during follicular growth, ovulation, and early luteal formation in the rat. Curry, T.E., Song, L., Wheeler, S.E. Biol. Reprod. (2001)
- Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats. Jeyabalan, A., Kerchner, L.J., Fisher, M.C., McGuane, J.T., Doty, K.D., Conrad, K.P. J. Appl. Physiol. (2006)
- Expression of matrix metalloproteinase -2, -9 and tissue inhibitors of metalloproteinase -1, -2, -3 mRNAs in rat uterus during early pregnancy. Zhao, Y.G., Xiao, A.Z., Cao, X.M., Zhu, C. Mol. Reprod. Dev. (2002)
- Gelatinases A and B are up-regulated in rat lungs by subacute hyperoxia: pathogenetic implications. Pardo, A., Barrios, R., Maldonado, V., Meléndez, J., Pérez, J., Ruiz, V., Segura-Valdez, L., Sznajder, J.I., Selman, M. Am. J. Pathol. (1998)
- Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Phillips, P.A., McCarroll, J.A., Park, S., Wu, M.J., Pirola, R., Korsten, M., Wilson, J.S., Apte, M.V. Gut (2003)
- Expression and activity of matrix metalloproteinase-2 and -9 in experimental granulation tissue. Inkinen, K., Turakainen, H., Wolff, H., Ravanti, L., Kähäri, V.M., Ahonen, J. APMIS (2000)
- Follicle-stimulating hormone increases the expression of tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 and induces TIMP-1 AP-1 site binding complex(es) in prepubertal rat Sertoli cells. Ulisse, S., Farina, A.R., Piersanti, D., Tiberio, A., Cappabianca, L., D'Orazi, G., Jannini, E.A., Malykh, O., Stetler-Stevenson, W.G., D'Armiento, M. Endocrinology (1994)
- Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid. Reif, S., Aeed, H., Shilo, Y., Reich, R., Kloog, Y., Kweon, Y.O., Bruck, R. J. Hepatol. (2004)
- Enzymes active in the areas undergoing cartilage resorption during the development of the secondary ossification center in the tibiae of rats aged 0-21 days: II. Two proteinases, gelatinase B and collagenase-3, are implicated in the lysis of collagen fibrils. Davoli, M.A., Lamplugh, L., Beauchemin, A., Chan, K., Mordier, S., Mort, J.S., Murphy, G., Docherty, A.J., Leblond, C.P., Lee, E.R. Dev. Dyn. (2001)
- Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis. Kossakowska, A.E., Edwards, D.R., Lee, S.S., Urbanski, L.S., Stabbler, A.L., Zhang, C.L., Phillips, B.W., Zhang, Y., Urbanski, S.J. Am. J. Pathol. (1998)
- Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Rosenberg, G.A., Estrada, E.Y., Dencoff, J.E. Stroke (1998)
- Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Peterson, J.T., Li, H., Dillon, L., Bryant, J.W. Cardiovasc. Res. (2000)
- Irradiation of rat mesangial cells alters the expression of gene products associated with the development of renal fibrosis. Zhao, W., O'Malley, Y., Robbins, M.E. Radiat. Res. (1999)
- Effects of hypoxia, hyperoxia on the regulation of expression and activity of matrix metalloproteinase-2 in hepatic stellate cells. Chen, P.S., Zhai, W.R., Zhou, X.M., Zhang, J.S., Zhang, Y.E., Ling, Y.Q., Gu, Y.H. World J. Gastroenterol. (2001)
- Epithelial cells up-regulate matrix metalloproteinases in cells within the same mammary carcinoma that have undergone an epithelial-mesenchymal transition. Martorana, A.M., Zheng, G., Crowe, T.C., O'Grady, R.L., Lyons, J.G. Cancer Res. (1998)