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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TIMP2  -  TIMP metallopeptidase inhibitor 2

Macaca mulatta

 
 
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Disease relevance of TIMP-2

 

High impact information on TIMP-2

  • We hypothesized that LH or progesterone (P) regulate interstitial-collagenase (MMP-1), the gelatinases (MMP-2 and -9), TIMP-1, and TIMP-2 in the CL [2].
  • Changes in gene expression were determined by RT-PCR and quantified by real-time PCR for urokinase plasminogen activator (uPA), collagenase-1 (MMP-1), membrane type-1 metalloproteinase (MT1-MMP), gelatinases A and B (MMP-2, MMP-9), tissue inhibitor-2 (TIMP-2), VEGF and its receptors, Flt-1 (VEGFR-1), KDR (VEGFR-2), and neuropilin-1 (NP-1) [1].
  • At the site of transection, MT1-MMP, MMP1, MMP2, TIMP1 and TIMP2 were expressed by reactive astrocytes [3].
 

Anatomical context of TIMP-2

  • Constitutive expression of MMP2, TIMP1 and TIMP2 in retinal ganglion cells suggests a role in maintenance of synaptic integrity and plasticity and maintenance of the periaxonal space [3].
 

Associations of TIMP-2 with chemical compounds

  • Administration of a 3beta-hydroxysteroid dehydrogenase inhibitor (Trilostane [TRL]) during hCG treatment decreased (p < 0.05) mRNA levels for interstitial collagenase, gelatinase B, matrilysin, TIMP-1, and TIMP-2 [4].

References

  1. Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells: Involvement of cytosolic phospholipase A2 activity. Ottino, P., Finley, J., Rojo, E., Ottlecz, A., Lambrou, G.N., Bazan, H.E., Bazan, N.G. Mol. Vis. (2004) [Pubmed]
  2. Gonadotropin and steroid regulation of matrix metalloproteinases and their endogenous tissue inhibitors in the developed corpus luteum of the rhesus monkey during the menstrual cycle. Young, K.A., Stouffer, R.L. Biol. Reprod. (2004) [Pubmed]
  3. Differential expression of matrix metalloproteinases in monkey eyes with experimental glaucoma or optic nerve transection. Agapova, O.A., Kaufman, P.L., Lucarelli, M.J., Gabelt, B.T., Hernandez, M.R. Brain Res. (2003) [Pubmed]
  4. Expression of matrix metalloproteinases and their tissue inhibitor messenger ribonucleic acids in macaque periovulatory granulosa cells: time course and steroid regulation. Chaffin, C.L., Stouffer, R.L. Biol. Reprod. (1999) [Pubmed]
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