Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

CTF1 - cardiotrophin 1

Canis lupus familiaris

Jougasaki, M. et al., Jougasaki, M. et al., Jougasaki, M. et al.

Jougasaki, Larsen, Cataliotti, Christiansen, Burnett, Jougasaki, Leskinen, Larsen, Luchner, Cataliotti, Tachibana, Burnett,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CTF1

Both cardiotrophin-1 (CT-1) and B-type or brain natriuretic peptide (BNP) are activated by cardiomyocyte stretch, and gene expression of CT-1 and BNP are augmented in the heart in experimental and human congestive heart failure (CHF) [1].
The goal of this study was to define cardiac gene expression of CT-1 and BNP by Northern blot analysis in normal (n=5), early left ventricular dysfunction (ELVD, n=5) and overt CHF dogs (n=5), in which ventricular function is progressively decreased [1].

High impact information on CTF1

Northern blot analysis demonstrated that CT-1 gene expression was present in normal atrium and ventricle and was increased in CHF hearts [2].
Augmented cardiac cardiotrophin-1 in experimental congestive heart failure [2].
This study reports differential regulation of gene expression of CT-1 and BNP in the heart during the progression of CHF, and demonstrates that ventricular CT-1 gene activation precedes ventricular BNP gene activation [1].
The present study, therefore, reports the presence of CT-1 and gp130 in vascular endothelial cells and mechanisms of secretion of ET-1 related to this cytokine system [3].
Cardiotrophin-1 stimulates endothelin-1 via gp130 in vascular endothelial cells [3].

Associations of CTF1 with chemical compounds

Cardiotrophin-1 (CT-1) is a new member of the interleukin-6-type cytokines that induce biological actions through the glycoprotein (gp) 130 [3].

References

Ventricular cardiotrophin-1 activation precedes BNP in experimental heart failure. Jougasaki, M., Leskinen, H., Larsen, A.M., Luchner, A., Cataliotti, A., Tachibana, I., Burnett, J.C. Peptides (2003) [Pubmed]
Augmented cardiac cardiotrophin-1 in experimental congestive heart failure. Jougasaki, M., Tachibana, I., Luchner, A., Leskinen, H., Redfield, M.M., Burnett, J.C. Circulation (2000) [Pubmed]
Cardiotrophin-1 stimulates endothelin-1 via gp130 in vascular endothelial cells. Jougasaki, M., Larsen, A.M., Cataliotti, A., Christiansen, D.C., Burnett, J.C. Peptides (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

CTF1	Bos taurus
CTF1	Homo sapiens
CTF1	Macaca mulatta
Ctf1	Mus musculus
CTF1	Pan troglodytes
Ctf1	Rattus norvegicus

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.