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Gene Review:

IGFBP6 - insulin-like growth factor binding protein 6

Bos taurus

Cohick, W.S. et al., Booth, B.A. et al., Dake, B.L. et al., Llewellyn, S. et al., Booth, B.A. et al., et al.

Llewellyn, Fitzpatrick, Kenny, Murphy, Scaramuzzi, Wathes,

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Disease relevance of IGFBP6

IGFBP-6 mRNA expression was low and increased in both cell types with exposure to hypoxia [1].

High impact information on IGFBP6

The orientation of this fusion protein's structure has the N terminus of IGFBP-3 fused to the C terminus of IGFBP-6, leaving the key binding areas of each open [2].
The decrease in IGFBP-6 was less marked when cells were treated with a combination of IGF-I and forskolin [3].
In contrast, forskolin decreased IGFBP-6 mRNA relative to controls, but had no effect on IGFBP-2 [3].
The homologous region of IGFBP-6 (P6) also stimulated sulfate uptake, but less potently than P3 and P5 [4].
The pattern of IGFBP-6 mRNA expression in theca paralleled that of IGF-II mRNA, with higher (P < 0.05) levels in healthy, very small follicles [5].

Associations of IGFBP6 with chemical compounds

Peptides of 18 amino acids were synthesized, corresponding to a common basic region of IGFBP-3 (P3), IGFBP-5 and IGFBP-6 (P6) which contained a heparin binding sequence [6].
However, retinoic acid (10(-6) M) stimulated both IGFBP-2 and IGFBP-6 protein and mRNA levels, but it decreased IGFBP-3 mRNA levels relative to controls [3].

Analytical, diagnostic and therapeutic context of IGFBP6

No IGFBP-6 was found by immunoprecipitation [7].

References

Modulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells. Tucci, M., Nygard, K., Tanswell, B.V., Farber, H.W., Hill, D.J., Han, V.K. J. Endocrinol. (1998) [Pubmed]
Effect of an insulin-like growth factor binding protein fusion protein on thymidine incorporation in neuroblastoma and rhabdomyosarcoma cell lines. Dake, B.L., Boes, M., Bach, L.A., Bar, R.S. Endocrinology (2004) [Pubmed]
Regulation of IGF binding protein synthesis by a bovine mammary epithelial cell line. Cohick, W.S., Turner, J.D. J. Endocrinol. (1998) [Pubmed]
Effect of IGFBP-derived peptides on incorporation of(35)SO(4)into proteoglycans. Booth, B.A., Boes, M., Dake, B.L., Caldwell, E.E., Weiler, J.M., Bar, R.S. Growth Horm. IGF Res. (2000) [Pubmed]
Effect of negative energy balance on the insulin-like growth factor system in pre-recruitment ovarian follicles of post partum dairy cows. Llewellyn, S., Fitzpatrick, R., Kenny, D.A., Murphy, J.J., Scaramuzzi, R.J., Wathes, D.C. Reproduction (2007) [Pubmed]
IGFBP-3 and IGFBP-5 association with endothelial cells: role of C-terminal heparin binding domain. Booth, B.A., Boes, M., Andress, D.L., Dake, B.L., Kiefer, M.C., Maack, C., Linhardt, R.J., Bar, K., Caldwell, E.E., Weiler, J. Growth Regul. (1995) [Pubmed]
Insulin-like growth factor system in bovine first-wave dominant and subordinate follicles. de la Sota, R.L., Simmen, F.A., Diaz, T., Thatcher, W.W. Biol. Reprod. (1996) [Pubmed]

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IGFBP6	Canis lupus familiaris
IGFBP6	Homo sapiens
Igfbp6	Mus musculus
IGFBP6	Pan troglodytes
Igfbp6	Rattus norvegicus

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