The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

IGFBP6  -  insulin-like growth factor binding protein 6

Homo sapiens

Synonyms: IBP-6, IBP6, IGF-binding protein 6, IGFBP-6, Insulin-like growth factor-binding protein 6
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of IGFBP6


High impact information on IGFBP6

  • IGFBP-2 and IGFBP-4 are secreted primarily into the basolateral side (71 and 87%, respectively), whereas IGFBP-6 is targeted to the apical surface (76%) as a possible consequence of an active sorting [1].
  • This study indicates (a) that IGF-II is potentially capable of autocrine regulation on the basolateral side of HT29-D4-GAL cell, and (b) that IGFBP-6 has a unique pattern of secretory polarity [1].
  • Western immunoblot analysis also demonstrated increased intact IGFBP-2 but decreased IGFBP-6 in the presence of N-myc oncogene [6].
  • Our findings show that IGFBP-6 influences neuroblastoma cell growth, both in vitro and in experimental xenograft development [7].
  • The N-terminal linkages of IGFBP-6 differ significantly from those of IGFBP-1 (and, by implication, the other IGFBPs), which could contribute to the distinctive IGF binding properties of IGFBP-6 [8].

Chemical compound and disease context of IGFBP6


Biological context of IGFBP6


Anatomical context of IGFBP6

  • IGFBP-6 was expressed in greater abundance in the decidua parietalis than in decidua basalis, although the general level of expression was low [15].
  • Moderate expression of the IGFBP-4 and IGFBP-5 genes was seen in all cell types, including stromal cells, but no IGFBP-6 mRNA was detected [16].
  • Human fibroblast IGFBP-6 expression was stable under the different culture conditions; IGFBP-1 and -2 mRNA were not detected [17].
  • The IGFBP-6 mRNA expression showed a significant cyclic variation in normal endometrium, with low levels in late-proliferative and early- to mid-secretory phases and high expression in late-secretory and early-proliferative phases [2].
  • IGFBP-3, IGFBP-5 and IGFBP-6 were expressed in approximately 50% of cell lines [18].

Associations of IGFBP6 with chemical compounds


Physical interactions of IGFBP6

  • In summary, a specific antiserum and RIA were used to demonstrate elevated levels of intact IGF-II-binding IGFBP-6 in serum of CRF children [23].

Regulatory relationships of IGFBP6


Other interactions of IGFBP6

  • IGFBP-6 differs from other IGFBPs in having the highest affinity for IGF-II and in binding IGF-I with 20-100-fold lower affinity [8].
  • The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry [8].
  • CONCLUSION: Lower serum concentrations of IGFBP-6, -3 and -1, but higher PSA concentrations were seen in the breast cancer group, and collectively these would suggest that there is an increase in bioavailable IGF-I in breast cancer [5].
  • In media treated with plasminogen, in which IGFBP-2 was proteolysed, IGFBP-6 was increased [12].
  • IGFBP-6 and type 1 and 2 IGF receptor mRNA expression was detectable in all ovarian compartments only by RT-PCR [28].

Analytical, diagnostic and therapeutic context of IGFBP6


  1. Cell polarity of the insulin-like growth factor system in human intestinal epithelial cells. Unique apical sorting of insulin-like growth factor binding protein-6 in differentiated human colon cancer cells. Remacle-Bonnet, M., Garrouste, F., el Atiq, F., Marvaldi, J., Pommier, G. J. Clin. Invest. (1995) [Pubmed]
  2. Suppressed expression of insulin-like growth factor binding protein-1 mRNA in the endometrium: a molecular mechanism associating endometrial cancer with its risk factors. Rutanen, E.M., Nyman, T., Lehtovirta, P., Ammälä, M., Pekonen, F. Int. J. Cancer (1994) [Pubmed]
  3. IGF-binding protein-6 is involved in growth inhibition in SH-SY5Y human neuroblastoma cells: its production is both IGF- and cell density-dependent. Babajko, S., Leneuve, P., Loret, C., Binoux, M. J. Endocrinol. (1997) [Pubmed]
  4. Circulating levels of human insulin-like growth factor binding protein-6 (IGFBP-6) in health and disease as determined by radioimmunoassay. Van Doorn, J., Ringeling, A.M., Shmueli, S.S., Kuijpers, M.C., Hokken-Koelega, A.C., van Buul-Offers, S.C., Jansen, M. Clin. Endocrinol. (Oxf) (1999) [Pubmed]
  5. Serum IGF-binding protein-6 and prostate specific antigen in breast cancer. Kaulsay, K.K., Ng, E.H., Ji, C.Y., Ho, G.H., Aw, T.C., Lee, K.O. Eur. J. Endocrinol. (1999) [Pubmed]
  6. N-myc regulation of type I insulin-like growth factor receptor in a human neuroblastoma cell line. Chambéry, D., Mohseni-Zadeh, S., de Gallé, B., Babajko, S. Cancer Res. (1999) [Pubmed]
  7. Expression of insulin-like growth factor-binding protein 6 complementary DNA alters neuroblastoma cell growth. Grellier, P., De Galle, B., Babajko, S. Cancer Res. (1998) [Pubmed]
  8. The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry. Neumann, G.M., Bach, L.A. J. Biol. Chem. (1999) [Pubmed]
  9. Insulin-like growth factor binding protein-6 activates programmed cell death in non-small cell lung cancer cells. Sueoka, N., Lee, H.Y., Wiehle, S., Cristiano, R.J., Fang, B., Ji, L., Roth, J.A., Hong, W.K., Cohen, P., Kurie, J.M. Oncogene (2000) [Pubmed]
  10. Insulin-like growth factor binding protein-6 inhibits prostate cancer cell proliferation: implication for anticancer effect of diethylstilbestrol in hormone refractory prostate cancer. Koike, H., Ito, K., Takezawa, Y., Oyama, T., Yamanaka, H., Suzuki, K. Br. J. Cancer (2005) [Pubmed]
  11. Regulation of insulin-like growth factor-binding-protein-1, 2, 3, 4, 5, and 6: synthesis, secretion, and gene expression in estrogen receptor-negative human breast carcinoma cells. Sheikh, M.S., Shao, Z.M., Hussain, A., Clemmons, D.R., Chen, J.C., Roberts, C.T., LeRoith, D., Fontana, J.A. J. Cell. Physiol. (1993) [Pubmed]
  12. The IGF system in neuroblastoma xenografts: focus on IGF-binding protein-6. Grellier, P., Berrebi, D., Peuchmaur, M., Babajko, S. J. Endocrinol. (2002) [Pubmed]
  13. Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene. Ehrenborg, E., Zazzi, H., Lagercrantz, S., Granqvist, M., Hillerbrand, U., Allander, S.V., Larsson, C., Luthman, H. Mamm. Genome (1999) [Pubmed]
  14. Identification of genes differentially expressed in testes containing carcinoma in situ. Hoei-Hansen, C.E., Nielsen, J.E., Almstrup, K., Hansen, M.A., Skakkebaek, N.E., Rajpert-DeMeyts, E., Leffers, H. Mol. Hum. Reprod. (2004) [Pubmed]
  15. The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface. Han, V.K., Bassett, N., Walton, J., Challis, J.R. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  16. Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins-1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries. el-Roeiy, A., Chen, X., Roberts, V.J., Shimasakai, S., Ling, N., LeRoith, D., Roberts, C.T., Yen, S.S. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  17. Effect of glucocorticoid on insulin-like growth factor (IGF) regulation of IGF-binding protein expression in fibroblasts. Conover, C.A., Clarkson, J.T., Bale, L.K. Endocrinology (1995) [Pubmed]
  18. Expression of the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs) in human gastric cancer cells. Yi, H.K., Hwang, P.H., Yang, D.H., Kang, C.W., Lee, D.Y. Eur. J. Cancer (2001) [Pubmed]
  19. Regulation of the insulin-like growth factors and their binding proteins by glucocorticoid and growth hormone in nonislet cell tumor hypoglycemia. Baxter, R.C., Holman, S.R., Corbould, A., Stranks, S., Ho, P.J., Braund, W. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  20. Inhibition of Caco-2 cell proliferation by all-trans retinoic acid: role of insulin-like growth factor binding protein-6. Kim, E.J., Kang, Y.H., Schaffer, B.S., Bach, L.A., MacDonald, R.G., Park, J.H. J. Cell. Physiol. (2002) [Pubmed]
  21. Retinoic acid regulates insulin-like growth factor-binding protein expression in human osteoblast cells. Zhou, Y., Mohan, S., Linkhart, T.A., Baylink, D.J., Strong, D.D. Endocrinology (1996) [Pubmed]
  22. MDCK cells secrete neutral proteases cleaving insulin-like growth factor-binding protein-2 to -6. Shalamanova, L., Kübler, B., Scharf, J.G., Braulke, T. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
  23. Insulin-like growth factor-binding protein-6 levels are elevated in serum of children with chronic renal failure: a report of the Southwest Pediatric Nephrology Study Group. Powell, D.R., Liu, F., Baker, B.K., Hintz, R.L., Durham, S.K., Brewer, E.D., Frane, J.W., Tonshoff, B., Mehls, O., Wingen, A.M., Watkins, S.L., Hogg, R.J., Lee, P.D. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  24. Radioimmunoassay of insulin-like growth factor-binding protein-6 in human serum and other body fluids. Baxter, R.C., Saunders, H. J. Endocrinol. (1992) [Pubmed]
  25. Differential secretory polarity of IGFBP-6 vs. IGFBP-2 and IGFBP-4 in human intestinal epithelial cells: is it a way of modulating IGF-II bioavailability towards the IGF-responsive basolateral surface? Pommier, G.J., Remacle-Bonnet, M.M., Tripier, S.G., Garrouste, F.L. Prog. Growth Factor Res. (1995) [Pubmed]
  26. Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors. Denys, H., Jadidizadeh, A., Amini Nik, S., Van Dam, K., Aerts, S., Alman, B.A., Cassiman, J.J., Tejpar, S. Oncogene (2004) [Pubmed]
  27. Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6. Fu, P., Thompson, J.A., Bach, L.A. J. Biol. Chem. (2007) [Pubmed]
  28. Expression of insulin-like growth factor (IGF), IGF-binding protein, and IGF receptor messenger ribonucleic acids in normal and polycystic ovaries. Voutilainen, R., Franks, S., Mason, H.D., Martikainen, H. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
WikiGenes - Universities