The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Igfbp6  -  insulin-like growth factor binding protein 6

Rattus norvegicus

Synonyms: IBP-6, IGF-BP6, IGF-binding protein 6, IGFBP-6, Igfbp-6, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Igfbp6


High impact information on Igfbp6

  • Human IGFBP-6 possesses a single Asn-linked glycosylation site near the carboxyl-terminal, whereas no potential Asn-linked glycosylation sites are present in the rat sequence [2].
  • A single 1.3-kilobase IGFBP-6 mRNA was detected by Northern analysis in all rat tissues examined, including testis, intestine, adrenal, kidney, stomach, spleen, heart, lung, brain, and liver, indicating that this BP is a ubiquitous protein [2].
  • Using amino acid sequence information from a tryptic fragment of pig IGFBP-6 to prepare a probe, cDNA clones encoding rat and human IGFBP-6 have been isolated and characterized [2].
  • Finally, and most strikingly, IGFBP-6 expression, barely detectable in the d7.0 myometrium, gradually increases until it is very strongly transcribed during the placental stages [3].
  • CONCLUSIONS: In the diabetic (mRen-2)27 rat, IGFBP-6 is downregulated and IGFBP-5 is upregulated by induction of diabetes [4].

Biological context of Igfbp6


Anatomical context of Igfbp6


Associations of Igfbp6 with chemical compounds


Physical interactions of Igfbp6


Regulatory relationships of Igfbp6


Other interactions of Igfbp6


Analytical, diagnostic and therapeutic context of Igfbp6


  1. Insulin-like Growth Factors and Their Binding Proteins Define Specific Phases of Myometrial Differentiation During Pregnancy in the Rat. Shynlova, O., Tsui, P., Dorogin, A., Langille, B.L., Lye, S.J. Biol. Reprod. (2007) [Pubmed]
  2. Isolation and molecular cloning of insulin-like growth factor-binding protein-6. Shimasaki, S., Gao, L., Shimonaka, M., Ling, N. Mol. Endocrinol. (1991) [Pubmed]
  3. Insulin-like growth factor binding protein gene expression in the pregnant rat uterus and placenta. Cerro, J.A., Pintar, J.E. Dev. Biol. (1997) [Pubmed]
  4. Expression of the IGF system in normal and diabetic transgenic (mRen-2)27 rat eye. Bergman, P.B., Moravski, C.J., Edmondson, S.R., Russo, V.C., Bach, L.A., Wilkinson-Berka, J.L., Werther, G.A. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  5. Structural characterization of the rat insulin-like growth factor binding protein-6 gene. Zhu, X., Ling, N., Shimasaki, S. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  6. Expression of insulin-like growth factors and corresponding binding proteins (IGFBP 1-6) in rat spinal cord and peripheral nerve after axonal injuries. Hammarberg, H., Risling, M., Hökfelt, T., Cullheim, S., Piehl, F. J. Comp. Neurol. (1998) [Pubmed]
  7. Insulin-like growth factor-binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells. Kühl, N.M., Hoekstra, D., De Vries, H., De Keyser, J. Glia (2003) [Pubmed]
  8. Structure-function relationships of insulin-like growth factor binding protein 6 (IGFBP-6) and its chimeras. Boes, M., Dake, B.L., Booth, B.A., Sandra, A., Bateman, M., Knudtson, K., Bar, R.S. Growth Horm. IGF Res. (2002) [Pubmed]
  9. Localization of mRNAs for insulin-like growth factor binding proteins 1 to 6 in rat kidney. Price, G.J., Berka, J.L., Edmondson, S.R., Werther, G.A., Bach, L.A. Kidney Int. (1995) [Pubmed]
  10. Cortisol enhances the transcription of insulin-like growth factor-binding protein-6 in cultured osteoblasts. Gabbitas, B., Canalis, E. Endocrinology (1996) [Pubmed]
  11. Regulation of IGF-binding protein-6 by dexamethasone and IGFs in PC12 rat phaeochromocytoma cells. Bach, L.A., Leeding, K.S., Leng, S.L. J. Endocrinol. (1997) [Pubmed]
  12. Retinoic acid stimulates the transcription of insulin-like growth factor binding protein-6 in skeletal cells. Gabbitas, B., Canalis, E. J. Cell. Physiol. (1996) [Pubmed]
  13. Growth factor regulation of insulin-like growth factor binding protein-6 expression in osteoblasts. Gabbitas, B., Canalis, E. J. Cell. Biochem. (1997) [Pubmed]
  14. Cellular localization of messenger RNAs for insulin-like growth factors (IGFs), their receptors and binding proteins during fetal rat lung development. Retsch-Bogart, G.Z., Moats-Staats, B.M., Howard, K., D'Ercole, A.J., Stiles, A.D. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  15. Localization of mRNAs for insulin-like growth factor-I (IGF-I), IGF-I receptor, and IGF binding proteins in rat eye. Burren, C.P., Berka, J.L., Edmondson, S.R., Werther, G.A., Batch, J.A. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  16. Phenotypic expression of IGF binding protein transcripts in muscle, in vitro and in vivo. Bayol, S., Loughna, P.T., Brownson, C. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  17. Effect of protein restriction on the messenger RNA contents of bone-matrix proteins, insulin-like growth factors and insulin-like growth factor binding proteins in femur of ovariectomized rats. Higashi, Y., Takenaka, A., Takahashi, S.I., Noguchi, T. Br. J. Nutr. (1996) [Pubmed]
WikiGenes - Universities