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Gene Review

IGFBP5  -  insulin-like growth factor binding protein 5

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Disease relevance of IGFBP5


High impact information on IGFBP5


Biological context of IGFBP5


Anatomical context of IGFBP5


Associations of IGFBP5 with chemical compounds


Regulatory relationships of IGFBP5


Other interactions of IGFBP5

  • In contrast, IGF-1 but not IGF-2 increased (P < 0.01) thecal IGFBP-5 mRNA levels [16].
  • In Experiment 3A, insulin enhanced production of IGFBP-5 by thecal cells whereas glucagon blocked insulin's stimulatory effect [17].
  • Hepatic HGF and IGFBP-5 mRNA levels did not differ between implanted and nonimplanted steers [18].

Analytical, diagnostic and therapeutic context of IGFBP5


  1. Modulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells. Tucci, M., Nygard, K., Tanswell, B.V., Farber, H.W., Hill, D.J., Han, V.K. J. Endocrinol. (1998) [Pubmed]
  2. Vascular endothelial growth factor and transforming growth factor-beta1 regulate the expression of insulin-like growth factor-binding protein-3, -4, and -5 in large vessel endothelial cells. Dahlfors, G., Arnqvist, H.J. Endocrinology (2000) [Pubmed]
  3. Insulin-like growth factor (IGF)-binding protein-4 proteolytic degradation in bovine, equine, and porcine preovulatory follicles: regulation by IGFs and heparin-binding domain-containing peptides. Mazerbourg, S., Zapf, J., Bar, R.S., Brigstock, D.R., Monget, P. Biol. Reprod. (2000) [Pubmed]
  4. Bovine oviductal and embryonic insulin-like growth factor binding proteins: possible regulators of "embryotrophic" insulin-like growth factor circuits. Winger, Q.A., de los Rios, P., Han, V.K., Armstrong, D.T., Hill, D.J., Watson, A.J. Biol. Reprod. (1997) [Pubmed]
  5. Insulin-like growth factor I and insulin-like growth factor-binding proteins in bovine serum and follicular fluid before and after the preovulatory surge of luteinizing hormone. Funston, R.N., Seidel, G.E., Klindt, J., Roberts, A.J. Biol. Reprod. (1996) [Pubmed]
  6. Mechanical regulation of IGF-I and IGF-binding protein gene transcription in bladder smooth muscle cells. Chaqour, B., Han, J.S., Tamura, I., Macarak, E. J. Cell. Biochem. (2002) [Pubmed]
  7. Role of prolactin, growth hormone and insulin-like growth factor 1 in mammary gland involution in the dairy cow. Accorsi, P.A., Pacioni, B., Pezzi, C., Forni, M., Flint, D.J., Seren, E. J. Dairy Sci. (2002) [Pubmed]
  8. Growth hormone suppresses the expression of IGFBP-5, and promotes the IGF-I-induced phosphorylation of Akt in bovine mammary epithelial cells. Sakamoto, K., Yano, T., Kobayashi, T., Hagino, A., Aso, H., Obara, Y. Domest. Anim. Endocrinol. (2007) [Pubmed]
  9. Propionibacteria fed to dairy cows: effects on energy balance, plasma metabolites and hormones, and reproduction. Francisco, C.C., Chamberlain, C.S., Waldner, D.N., Wettemann, R.P., Spicer, L.J. J. Dairy Sci. (2002) [Pubmed]
  10. Effect of negative energy balance on the insulin-like growth factor system in pre-recruitment ovarian follicles of post partum dairy cows. Llewellyn, S., Fitzpatrick, R., Kenny, D.A., Murphy, J.J., Scaramuzzi, R.J., Wathes, D.C. Reproduction (2007) [Pubmed]
  11. IGF paracrine and autocrine interactions between conceptus and oviduct. Watson, A.J., Westhusin, M.E., Winger, Q.A. J. Reprod. Fertil. Suppl. (1999) [Pubmed]
  12. Pregnancy-associated plasma protein-A and insulin-like growth factor binding protein mRNAs in granulosa cells of dominant and subordinate follicles of preovulatory cattle. Santiago, C.A., Voge, J.L., Aad, P.Y., Allen, D.T., Stein, D.R., Malayer, J.R., Spicer, L.J. Domest. Anim. Endocrinol. (2005) [Pubmed]
  13. Alterations in follicular IGFBP mRNA expression and follicular fluid IGFBP concentrations during the first follicle wave in beef heifers. Canty, M.J., Boland, M.P., Evans, A.C., Crowe, M.A. Anim. Reprod. Sci. (2006) [Pubmed]
  14. Quantification of insulin-like growth factor binding protein mRNA using real-time PCR in bovine granulosa and theca cells: effect of estradiol, insulin, and gonadotropins. Voge, J.L., Santiago, C.A., Aad, P.Y., Goad, D.W., Malayer, J.R., Spicer, L.J. Domest. Anim. Endocrinol. (2004) [Pubmed]
  15. IGFBP-3 and IGFBP-5 association with endothelial cells: role of C-terminal heparin binding domain. Booth, B.A., Boes, M., Andress, D.L., Dake, B.L., Kiefer, M.C., Maack, C., Linhardt, R.J., Bar, K., Caldwell, E.E., Weiler, J. Growth Regul. (1995) [Pubmed]
  16. Effect of insulin-like growth factors (IGF), FSH, and leptin on IGF-binding-protein mRNA expression in bovine granulosa and theca cells: quantitative detection by real-time PCR. Voge, J.L., Aad, P.Y., Santiago, C.A., Goad, D.W., Malayer, J.R., Allen, D., Spicer, L.J. Peptides (2004) [Pubmed]
  17. Hormonal control of ovarian cell production of insulin-like growth factor binding proteins. Chamberlain, C.S., Spicer, L.J. Mol. Cell. Endocrinol. (2001) [Pubmed]
  18. Growth factor messenger RNA levels in muscle and liver of steroid-implanted and nonimplanted steers. White, M.E., Johnson, B.J., Hathaway, M.R., Dayton, W.R. J. Anim. Sci. (2003) [Pubmed]
  19. Interactions between the ovary and the local IGF-I axis modulate mammary development in prepubertal heifers. Berry, S.D., Howard, R.D., Jobst, P.M., Jiang, H., Akers, R.M. J. Endocrinol. (2003) [Pubmed]
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