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Gene Review:

IGFBP5 - insulin-like growth factor binding protein 5

Bos taurus

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Disease relevance of IGFBP5

IGFBP-5 was expressed only in BAEC and decreased with exposure to hypoxia [1].

High impact information on IGFBP5

At the protein level, IGF-I clearly increased IGFBP-5 levels in conditioned medium [2].
Vascular endothelial growth factor inhibited IGFBP-3 mRNA (P < 0.01) and protein expression and increased IGFBP-5 mRNA (P < 0.001) and protein [2].
In bovine atretic follicles, IGFBP-5 would also strengthen the inhibition of IGFBP-4 degradation by direct interaction of its HBD with the protease [3].
Messenger RNAs encoding IGFBPs -2, -3, and -4 were detected throughout bovine preattachment development, while transcripts encoding IGFBP-5 were detected only in blastocysts [4].
Serum contained IGFBP-2, -3, and -4, but not IGFBP-5 [5].

Biological context of IGFBP5

Conversely, the gene expression of IGFBP-5 was upregulated in stretched cells, and neutralizing antibodies to IGF-I blocked this activation [6].
After 24 h of culture, we determined the level of apoptosis through evaluation of DNA laddering in the oligonucleosomal fraction and examined IGFBP-5 messenger RNA (mRNA) expression [7].
The phosphorylation of Akt was inhibited in a dose-dependent manner when IGFBP-5 was added at varying concentrations and was also inhibited in the presence of IGFBP-3 [8].
These data demonstrate a relationship between levels of apoptosis and IGFBP-5 mRNA expression in the bovine mammary gland and confirm the involvement of this binding protein programmed cell death and its relationship with the main lactogenic hormones [7].
Plasma IGFBP-2 and IGFBP-5 levels decreased with week postpartum [9].

Anatomical context of IGFBP5

IGF-1R, IGFBP-4 and IGFBP-5 mRNA expression were not significantly altered by follicle size or health, but IGFBP-5 tended to increase in atretic follicles [10].
In addition, early embryos express mRNAs encoding IGF-binding proteins (IGFBPs) 2-5 from the one-cell to the blastocyst stage and IGFBP5 mRNA at the blastocyst stage [11].
IGFBP-5 mRNA in granulosa cells decreased (P < 0.05) 62% to 92%, between 24h and 48 h post-PGF2 alpha [12].
IGFBP-5 concentrations were higher (P < 0.05) in follicular fluid of F3 follicles at 108 h compared with the F3 at 36 h [13].
Estradiol decreased (P<0.05) IGFBP-2, -3, and -4 mRNA levels but had no effect on IGFBP-5 mRNA levels in theca cells [14].

Associations of IGFBP5 with chemical compounds

The 31-kDa form of IGFBP-5 was positively correlated with concentration of progesterone [5].
The amount of 28-29-kDa IGFBPs (small form of IGFBP-5 and [or] glycosylated form of IGFBP-4) was inversely associated with concentrations of androstenedione [5].
Estradiol (3 and 300 ng/ml) decreased (P<0.05) IGFBP-5 mRNA levels in large-follicle granulosa cells [14].
Of the 6 IGFBPs, IGFBP-3 and IGFBP-5 had the greatest heparin affinity [15].

Regulatory relationships of IGFBP5

Growth hormone suppresses the expression of IGFBP-5, and promotes the IGF-I-induced phosphorylation of Akt in bovine mammary epithelial cells [8].

Other interactions of IGFBP5

In contrast, IGF-1 but not IGF-2 increased (P < 0.01) thecal IGFBP-5 mRNA levels [16].
In Experiment 3A, insulin enhanced production of IGFBP-5 by thecal cells whereas glucagon blocked insulin's stimulatory effect [17].
Hepatic HGF and IGFBP-5 mRNA levels did not differ between implanted and nonimplanted steers [18].

Analytical, diagnostic and therapeutic context of IGFBP5

Expression of IGFBP-3 and IGFBP-5 mRNA were not influenced by ovariectomy [19].

References

Modulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells. Tucci, M., Nygard, K., Tanswell, B.V., Farber, H.W., Hill, D.J., Han, V.K. J. Endocrinol. (1998) [Pubmed]
Vascular endothelial growth factor and transforming growth factor-beta1 regulate the expression of insulin-like growth factor-binding protein-3, -4, and -5 in large vessel endothelial cells. Dahlfors, G., Arnqvist, H.J. Endocrinology (2000) [Pubmed]
Insulin-like growth factor (IGF)-binding protein-4 proteolytic degradation in bovine, equine, and porcine preovulatory follicles: regulation by IGFs and heparin-binding domain-containing peptides. Mazerbourg, S., Zapf, J., Bar, R.S., Brigstock, D.R., Monget, P. Biol. Reprod. (2000) [Pubmed]
Bovine oviductal and embryonic insulin-like growth factor binding proteins: possible regulators of "embryotrophic" insulin-like growth factor circuits. Winger, Q.A., de los Rios, P., Han, V.K., Armstrong, D.T., Hill, D.J., Watson, A.J. Biol. Reprod. (1997) [Pubmed]
Insulin-like growth factor I and insulin-like growth factor-binding proteins in bovine serum and follicular fluid before and after the preovulatory surge of luteinizing hormone. Funston, R.N., Seidel, G.E., Klindt, J., Roberts, A.J. Biol. Reprod. (1996) [Pubmed]
Mechanical regulation of IGF-I and IGF-binding protein gene transcription in bladder smooth muscle cells. Chaqour, B., Han, J.S., Tamura, I., Macarak, E. J. Cell. Biochem. (2002) [Pubmed]
Role of prolactin, growth hormone and insulin-like growth factor 1 in mammary gland involution in the dairy cow. Accorsi, P.A., Pacioni, B., Pezzi, C., Forni, M., Flint, D.J., Seren, E. J. Dairy Sci. (2002) [Pubmed]
Growth hormone suppresses the expression of IGFBP-5, and promotes the IGF-I-induced phosphorylation of Akt in bovine mammary epithelial cells. Sakamoto, K., Yano, T., Kobayashi, T., Hagino, A., Aso, H., Obara, Y. Domest. Anim. Endocrinol. (2007) [Pubmed]
Propionibacteria fed to dairy cows: effects on energy balance, plasma metabolites and hormones, and reproduction. Francisco, C.C., Chamberlain, C.S., Waldner, D.N., Wettemann, R.P., Spicer, L.J. J. Dairy Sci. (2002) [Pubmed]
Effect of negative energy balance on the insulin-like growth factor system in pre-recruitment ovarian follicles of post partum dairy cows. Llewellyn, S., Fitzpatrick, R., Kenny, D.A., Murphy, J.J., Scaramuzzi, R.J., Wathes, D.C. Reproduction (2007) [Pubmed]
IGF paracrine and autocrine interactions between conceptus and oviduct. Watson, A.J., Westhusin, M.E., Winger, Q.A. J. Reprod. Fertil. Suppl. (1999) [Pubmed]
Pregnancy-associated plasma protein-A and insulin-like growth factor binding protein mRNAs in granulosa cells of dominant and subordinate follicles of preovulatory cattle. Santiago, C.A., Voge, J.L., Aad, P.Y., Allen, D.T., Stein, D.R., Malayer, J.R., Spicer, L.J. Domest. Anim. Endocrinol. (2005) [Pubmed]
Alterations in follicular IGFBP mRNA expression and follicular fluid IGFBP concentrations during the first follicle wave in beef heifers. Canty, M.J., Boland, M.P., Evans, A.C., Crowe, M.A. Anim. Reprod. Sci. (2006) [Pubmed]
Quantification of insulin-like growth factor binding protein mRNA using real-time PCR in bovine granulosa and theca cells: effect of estradiol, insulin, and gonadotropins. Voge, J.L., Santiago, C.A., Aad, P.Y., Goad, D.W., Malayer, J.R., Spicer, L.J. Domest. Anim. Endocrinol. (2004) [Pubmed]
IGFBP-3 and IGFBP-5 association with endothelial cells: role of C-terminal heparin binding domain. Booth, B.A., Boes, M., Andress, D.L., Dake, B.L., Kiefer, M.C., Maack, C., Linhardt, R.J., Bar, K., Caldwell, E.E., Weiler, J. Growth Regul. (1995) [Pubmed]
Effect of insulin-like growth factors (IGF), FSH, and leptin on IGF-binding-protein mRNA expression in bovine granulosa and theca cells: quantitative detection by real-time PCR. Voge, J.L., Aad, P.Y., Santiago, C.A., Goad, D.W., Malayer, J.R., Allen, D., Spicer, L.J. Peptides (2004) [Pubmed]
Hormonal control of ovarian cell production of insulin-like growth factor binding proteins. Chamberlain, C.S., Spicer, L.J. Mol. Cell. Endocrinol. (2001) [Pubmed]
Growth factor messenger RNA levels in muscle and liver of steroid-implanted and nonimplanted steers. White, M.E., Johnson, B.J., Hathaway, M.R., Dayton, W.R. J. Anim. Sci. (2003) [Pubmed]
Interactions between the ovary and the local IGF-I axis modulate mammary development in prepubertal heifers. Berry, S.D., Howard, R.D., Jobst, P.M., Jiang, H., Akers, R.M. J. Endocrinol. (2003) [Pubmed]

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