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Gene Review

Igfbp6  -  insulin-like growth factor binding protein 6

Mus musculus

Synonyms: IBP-6, IGF-binding protein 6, IGFBP-6, Igfbp-6, Insulin-like growth factor-binding protein 6
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Disease relevance of Igfbp6

  • Up-regulation of these binding proteins has been observed in association with actions of 1,25-dihydroxyvitamin D(3) in prostate cancer cells, and the data suggest a role for IGFBP-3 and IGFBP-6 in the suppression of prostate tumor cell growth [1].
  • This study describes the expression of the mouse IGFBP-6 which is unique among IGFBPs in its preferential binding of IGF II, in insect cells using the baculovirus system [2].
  • By stably expressing IGFBP-6 sense or anti-sense mRNA in the EL-4 line of mouse thymoma cells, it was possible to isolate clones in which IGFBP-6 expression was increased or decreased [3].

High impact information on Igfbp6

  • A significant difference was found in the patterns of IGFBP expression; production of both messenger RNA and protein for IGFBP-3 and IGFBP-6 was greatly increased in the M12asBP4 and ALVA31asBP4 cell lines [1].
  • Exogenous Shh peptide induced expression of Igfbp-6 in the developing prostate while the chemical inhibitor of Hedgehog signaling, cyclopamine, reduced its expression [4].
  • Among the six IGFBPs, IGFBP-2, -5, and -6 were detected in the mouse taste buds: IGFBP-2 and -5 immunoreactivity was seen in the majority of the taste bud cells, whereas IGFBP-6 immunoreactivity was found in the nerve fibers innervating the taste buds [5].
  • We also report distinct disturbances in the expression of brain-derived neurotrophic factor, insulin-like growth factor binding protein 6 and several neuropeptides at 2 and 3 weeks of age, that is, before an obvious behavioural phenotype can be observed [6].
  • The purified, O-glycosylated IGFBP-6 was functional as shown by IGF binding and by inhibition of IGF II-stimulated DNA synthesis in human fibroblasts [2].

Biological context of Igfbp6


Anatomical context of Igfbp6


Regulatory relationships of Igfbp6


Other interactions of Igfbp6


Analytical, diagnostic and therapeutic context of Igfbp6


  1. Inhibition of growth and increased expression of insulin-like growth factor-binding protein-3 (IGFBP-3) and -6 in prostate cancer cells stably transfected with antisense IGFBP-4 complementary deoxyribonucleic acid. Drivdahl, R.H., Sprenger, C., Trimm, K., Plymate, S.R. Endocrinology (2001) [Pubmed]
  2. Mouse insulin-like growth factor binding protein-6: expression, purification, characterization and histochemical localization. Putzer, P., Breuer, P., Götz, W., Gross, M., Kübler, B., Scharf, J.G., Schuller, A.G., Hartmann, H., Braulke, T. Mol. Cell. Endocrinol. (1998) [Pubmed]
  3. TCDD-induced apoptosis in EL-4 cells deficient of the aryl hydrocarbon receptor and down-regulation of IGFBP-6 prevented the apoptotic cell death. Park, J.H., Hahn, E.J., Kong, J.H., Cho, H.J., Yoon, C.S., Cheong, S.W., Oh, G.S., Youn, H.J. Toxicol. Lett. (2003) [Pubmed]
  4. Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development. Lipinski, R.J., Cook, C.H., Barnett, D.H., Gipp, J.J., Peterson, R.E., Bushman, W. Dev. Dyn. (2005) [Pubmed]
  5. Distinct expression pattern of insulin-like growth factor family in rodent taste buds. Suzuki, Y., Takeda, M., Sakakura, Y., Suzuki, N. J. Comp. Neurol. (2005) [Pubmed]
  6. MRI and in situ hybridization reveal early disturbances in brain size and gene expression in the megencephalic (mceph/mceph) mouse. Diez, M., Schweinhardt, P., Petersson, S., Wang, F.H., Lavebratt, C., Schalling, M., Hökfelt, T., Spenger, C. Eur. J. Neurosci. (2003) [Pubmed]
  7. Expression of IGFBPs in the developing mouse submandibular and von Ebner's glands. Suzuki, Y. Anat. Embryol. (2006) [Pubmed]
  8. Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice. Larsen, P.H., DaSilva, A.G., Conant, K., Yong, V.W. J. Neurosci. (2006) [Pubmed]
  9. TCDD-up-regulation of IGFBP-6 and IL-5R alpha subunit genes in vivo and in vitro. Park, J.H., Lee, S.W., Kim, I.T., Shin, B.S., Cheong, S.W., Cho, U.H., Huh, M.J., Oh, G.S. Mol. Cells (2001) [Pubmed]
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