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Gene Review

wbbL  -  pseudo

Escherichia coli str. K-12 substr. MG1655

 
 
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Disease relevance of wbbL

 

High impact information on wbbL

  • Rv3265c shows homology to the Escherichia coli gene wbbL, which encodes a dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol, alpha-3-L-rhamnosyltransferase [2].
  • The wbbL of the temperature-sensitive mutant contained a single-base change that converted what was a proline in mc(2)155 to a serine residue [2].
  • We analyzed a recombinant cosmid containing the wbbL gene by subcloning and determination of O-antigen production phenotype in E. coli DH5alpha by sodium dodecyl sulfate-polyacrylamide electrophoresis and Western blot experiments with S. marcescens O4 antiserum [3].
  • Subcloning and sequencing experiments showed that a 2,124-bp DNA fragment containing the rmlD and wbbL genes was responsible for the observed phenotypes [1].

References

  1. A gene (wbbL) from Serratia marcescens N28b (O4) complements the rfb-50 mutation of Escherichia coli K-12 derivatives. Rubirés, X., Saigi, F., Piqué, N., Climent, N., Merino, S., Albertí, S., Tomás, J.M., Regué, M. J. Bacteriol. (1997) [Pubmed]
  2. Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability. Mills, J.A., Motichka, K., Jucker, M., Wu, H.P., Uhlik, B.C., Stern, R.J., Scherman, M.S., Vissa, V.D., Pan, F., Kundu, M., Ma, Y.F., McNeil, M. J. Biol. Chem. (2004) [Pubmed]
  3. Genetic analysis of the Serratia marcescens N28b O4 antigen gene cluster. Saigí, F., Climent, N., Piqué, N., Sanchez, C., Merino, S., Rubirés, X., Aguilar, A., Tomás, J.M., Regué, M. J. Bacteriol. (1999) [Pubmed]
 
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