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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

corto  -  CG2530 gene product from transcript CG2530-RC

Drosophila melanogaster

Synonyms: 7128, CCF, CG2530, CP-1, Ccf, ...
 
 
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High impact information on corto

  • Mutations in ccf, a novel Drosophila gene encoding a chromosomal factor, affect progression through mitosis and interact with Pc-G mutations [1].
  • Finally, we show that the CCF protein binds to specific sites on polytene chromosomes, many of which are shared with the Posterior sex combs Pc-G protein [1].
  • Together, these results suggest a role for the CCF protein in the maintenance of chromosome structure during mitosis and interphase [1].
  • Mutations in ccf give rise to late larvae with small imaginal discs and to adults showing appendages of reduced size, consistent with CCF involvement in cell proliferation [1].
  • To understand better the role of ETP, we addressed genetic and molecular interactions between corto and dsp1 [2].
 

Biological context of corto

  • Our previous work has shown that corto, which codes for a chromodomain protein, and dsp1, which codes for an HMGB protein, belong to a class of genes called the Enhancers of trithorax and Polycomb (ETP) that interact with both PcG and trxG [2].
  • Neuroblast squash analyses show that CCF is required for proper condensation of mitotic chromosomes and, therefore, for progression through mitosis [1].
 

Physical interactions of corto

 

Other interactions of corto

  • Our results provide evidence that corto maintains the anterior border of Ubx expression in third-instar larvae [4].
  • The Drosophila corto gene interacts with E(z) as well as with genes encoding members of maintenance complexes, suggesting that it could play a role in the transition between the initiation and maintenance of PcG silencing [3].
  • CONCLUSION: Our results reveal that the proteins Corto and DSP1 are differently recruited to a Scr ME depending on whether the ME is active, as seen in S2 cells, or inactive, as in most embryonic cells [2].

References

  1. Mutations in ccf, a novel Drosophila gene encoding a chromosomal factor, affect progression through mitosis and interact with Pc-G mutations. Kodjabachian, L., Delaage, M., Maurel, C., Miassod, R., Jacq, B., Rosset, R. EMBO J. (1998) [Pubmed]
  2. Corto and DSP1 interact and bind to a maintenance element of the Scr Hox gene: understanding the role of Enhancers of trithorax and Polycomb. Salvaing, J., Decoville, M., Mouchel-Vielh, E., Bussière, M., Daulny, A., Boldyreva, L., Zhimulev, I., Locker, D., Peronnet, F. BMC Biol. (2006) [Pubmed]
  3. The Drosophila Corto protein interacts with Polycomb-group proteins and the GAGA factor. Salvaing, J., Lopez, A., Boivin, A., Deutsch, J.S., Peronnet, F. Nucleic Acids Res. (2003) [Pubmed]
  4. corto genetically interacts with Pc-G and trx-G genes and maintains the anterior boundary of Ultrabithorax expression in Drosophila larvae. Lopez, A., Higuet, D., Rosset, R., Deutsch, J., Peronnet, F. Mol. Genet. Genomics (2001) [Pubmed]
 
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