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Gene Review

Psc  -  Posterior sex combs

Drosophila melanogaster

Synonyms: 49Ea, CG3886, D-Bmi, Dmel\CG3886, PSC, ...
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High impact information on Psc


Biological context of Psc

  • There is an excellent correlation between the in vivo phenotypes of mutant Psc alleles and the structure and in vitro activities of the corresponding proteins, suggesting that the in vitro activities of PRC1 reflect essential functions of Psc in vivo [6].
  • We have analyzed the domains required for the association of Psc with ph and Pc by using the yeast two-hybrid system and an in vitro protein-binding assay [7].
  • We find evidence for transformations along both the anterior-posterior and dorsal-ventral axes in embryos of a variety of genotypes that include a null mutation in Psc [8].
  • On polytene chromosomes, we find Psc at 45 chromosomal loci where two other Pc-G proteins are present [9].
  • There exist suppressor and enhancer mutations that modify the z1 eye color, and this paper summarizes our studies of those belonging to the Suppressor 2 of zeste complex [Su(z)2-C] [10].

Anatomical context of Psc


Physical interactions of Psc

  • We show that ph and Psc coprecipitate with Pc from nuclear extracts [7].

Other interactions of Psc


Analytical, diagnostic and therapeutic context of Psc


  1. Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Alkema, M.J., van der Lugt, N.M., Bobeldijk, R.C., Berns, A., van Lohuizen, M. Nature (1995) [Pubmed]
  2. Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene. Brunk, B.P., Martin, E.C., Adler, P.N. Nature (1991) [Pubmed]
  3. Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. van Lohuizen, M., Frasch, M., Wientjens, E., Berns, A. Nature (1991) [Pubmed]
  4. Propagation of silencing; recruitment and repression of naive chromatin in trans by polycomb repressed chromatin. Lavigne, M., Francis, N.J., King, I.F., Kingston, R.E. Mol. Cell (2004) [Pubmed]
  5. Reconstitution of a functional core polycomb repressive complex. Francis, N.J., Saurin, A.J., Shao, Z., Kingston, R.E. Mol. Cell (2001) [Pubmed]
  6. Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function. King, I.F., Emmons, R.B., Francis, N.J., Wild, B., Müller, J., Kingston, R.E., Wu, C.T. Mol. Cell. Biol. (2005) [Pubmed]
  7. The Drosophila polycomb group protein Psc contacts ph and Pc through specific conserved domains. Kyba, M., Brock, H.W. Mol. Cell. Biol. (1998) [Pubmed]
  8. Phenotypic consequences and genetic interactions of a null mutation in the Drosophila Posterior Sex Combs gene. Adler, P.N., Martin, E.C., Charlton, J., Jones, K. Dev. Genet. (1991) [Pubmed]
  9. The Polycomb group gene Posterior Sex Combs encodes a chromosomal protein. Martin, E.C., Adler, P.N. Development (1993) [Pubmed]
  10. A genetic analysis of the Suppressor 2 of zeste complex of Drosophila melanogaster. Wu, C.T., Howe, M. Genetics (1995) [Pubmed]
  11. Directed overexpression of suppressor 2 of zeste and Posterior Sex Combs results in bristle abnormalities in Drosophila melanogaster. Sharp, E.J., Martin, E.C., Adler, P.N. Dev. Biol. (1994) [Pubmed]
  12. pc1 and psc1, zebrafish homologs of Drosophila Polycomb and Posterior sex combs, encode nuclear proteins capable of complex interactions. Kawamura, A., Yokota, S., Yamada, K., Inoue, H., Inohaya, K., Yamazaki, K., Yasumasu, I., Higashinakagawa, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  13. Mutations in ccf, a novel Drosophila gene encoding a chromosomal factor, affect progression through mitosis and interact with Pc-G mutations. Kodjabachian, L., Delaage, M., Maurel, C., Miassod, R., Jacq, B., Rosset, R. EMBO J. (1998) [Pubmed]
  14. The polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes. Strutt, H., Paro, R. Mol. Cell. Biol. (1997) [Pubmed]
  15. Polycomb group mutants exhibit mitotic defects in syncytial cell cycles of Drosophila embryos. O'Dor, E., Beck, S.A., Brock, H.W. Dev. Biol. (2006) [Pubmed]
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