Psychiatry related information on Or83b

• Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction [1].

High impact information on Or83b

• The non-canonical receptor Or83b, which is highly conserved across insect orders, dimerizes with odorant and pheromone receptors and is required for efficient localization of these proteins to dendrites of sensory neurons [2].
• The OR/OR83b complex is necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide [3].
• This atypical heteromeric and topological design appears to be an insect-specific solution for odor recognition, making the OR/OR83b complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors [3].
• Here we demonstrate that OR83b heterodimerizes with conventional ORs early in the endomembrane system in OSNs, couples these complexes to the conserved ciliary trafficking pathway, and is essential to maintain the OR/OR83b complex within the sensory cilia, where odor signal transduction occurs [3].
• Or83b, a receptor expressed in a large fraction of olfactory neurons including Or43b neurons, does not confer odor responsiveness in the absence of Or43b [4].

References