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MeSH Review

Disease Vectors

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Disease relevance of Disease Vectors


High impact information on Disease Vectors

  • This gut-specific black fly carboxypeptidase promoter provides a valuable tool for the study of disease vectors [2].
  • Mammalian hepatic carboxylesterases (CEs) play important roles in the detoxification of ester-containing pyrethroids, which are widely used for the control of agricultural pests and disease vectors such as mosquitoes [3].
  • Like other mosquitoes, the biting and host preference behaviors of this disease vector are largely influenced by its sense of smell, which is presumably facilitated by G protein-coupled receptor signaling cascades [4].
  • These results may have epidemiologic importance considering that permethrin-soaked bed nets are being used in many countries to control the biting activity of disease vectors [5].
  • Deltamethrin (DTM) is a synthetic pyrethroid insecticide used wideworld in agriculture, home pest control, protection of foodstuff, and disease vector control [6].

Associations of Disease Vectors with chemical compounds

  • Tammany Parish Mosquito Control, ADAPCO, Inc., and the Navy Disease Vector Ecology and Control Center, Naval Air Station, Jacksonville, FL [7].
  • Moreover, protection afforded by Deet, SS220, and Picaridin against the feeding of these three disease vectors on humans is mechanistically a consequence of the two chemical effects [8].
  • Four among these exhibited promising activity comparable to that of the conventional organophosphate, temephos, thus providing for the first time a possible reserve arsenal for the control of the guineaworm disease vector [9].
  • Field trials of slow-release formulations of chlorpyrifos and malathion for the control of Chagas's disease vectors [10].
  • While production and use of most of the listed chemicals will shortly be eliminated, there is widespread agreement that DDT will continue to be needed for disease vector control [11].

Gene context of Disease Vectors

  • This atypical heteromeric and topological design appears to be an insect-specific solution for odor recognition, making the OR/OR83b complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors [12].


  1. Initiating arbovirus surveillance in Arkansas, 2001. Kent, R.J., Lacer, L.D., Meisch, M.V. J. Med. Entomol. (2003) [Pubmed]
  2. Gut-specific transcriptional regulatory elements of the carboxypeptidase gene are conserved between black flies and Drosophila. Xiong, B., Jacobs-Lorena, M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Huang, H., Fleming, C.D., Nishi, K., Redinbo, M.R., Hammock, B.D. Chem. Res. Toxicol. (2005) [Pubmed]
  4. Identification of a chemosensory receptor from the yellow fever mosquito, Aedes aegypti, that is highly conserved and expressed in olfactory and gustatory organs. Melo, A.C., Rützler, M., Pitts, R.J., Zwiebel, L.J. Chem. Senses (2004) [Pubmed]
  5. Inheritance of larval resistance to permethrin in Aedes aegypti and association with sex ratio distortion and life history variation. Mebrahtu, Y.B., Norem, J., Taylor, M. Am. J. Trop. Med. Hyg. (1997) [Pubmed]
  6. Effects of deltamethrin on functions of rat liver mitochondria and on native and synthetic model membranes. Braguini, W.L., Cadena, S.M., Carnieri, E.G., Rocha, M.E., de Oliveira, M.B. Toxicol. Lett. (2004) [Pubmed]
  7. Aerial optimization and canopy penetration study of Dibrom 14 Concentrate. Brown, J.R., Reynolds, W.H., Palmisano, C., Taylor, V. J. Am. Mosq. Control Assoc. (2005) [Pubmed]
  8. Repellent and deterrent effects of SS220, Ppicaridin, and Deet suppress human blood feeding by Aedes aegypti, Anopheles stephensi, and Phlebotomus papatasi. Klun, J.A., Khrimian, A., Debboun, M. J. Med. Entomol. (2006) [Pubmed]
  9. Cyclopcidal activity of some new insect growth regulators. Sharma, R.N., Patwardhan, S.A., Tungikar, V.B., Deshpande, S.G. Indian J. Exp. Biol. (1989) [Pubmed]
  10. Field trials of slow-release formulations of chlorpyrifos and malathion for the control of Chagas's disease vectors. Pinchin, R., de Oliveira Filho, A.M., Gilbert, B. Revista brasileira de malariologia e doenças tropicais. Publicações avulsas. (1979) [Pubmed]
  11. Developing an international consensus on DDT: a balance of environmental protection and disease control. Walker, K.R., Ricciardone, M.D., Jensen, J. International journal of hygiene and environmental health. (2003) [Pubmed]
  12. Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo. Benton, R., Sachse, S., Michnick, S.W., Vosshall, L.B. PLoS Biol. (2006) [Pubmed]
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