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Gene Review

BMPR1B  -  bone morphogenetic protein receptor, type IB

Bos taurus

Synonyms: ALK6, BMP15, BMPR-IB, BMPRIB
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High impact information on BMPRIB

  • Reverse transcription polymerase chain reaction studies with antral follicles showed the expression of BMPR-IA, BMPR-IB, ActR-IA, ActR-IIB, BMPR-II and BMP4 mRNA in all follicular compartments, while BMP2 mRNA was generally restricted to theca and cumulus tissue [1].
  • It is suggested that in FecB(B)/FecB(B) ewes, Q249R substitution would impair the function of BMPR-IB, leading to a precocious differentiation of granulosa cells and of follicular maturation [2].
  • In particular, we and others have recently shown that a non-conservative substitution (Q249R) in the bone morphogenetic protein-receptor type IB (BMPR-IB) coding sequence is fully associated with the hyperprolific phenotype of FecB(B)/FecB(B) Booroola ewes [2].
  • GDF-9 and BMPs initiate signaling by assembling type I (ALK-3, ALK-5 and ALK-6) and type II (BMPRII) receptors [3].

Associations of BMPRIB with chemical compounds


  1. Expression of bone morphogenetic protein2 (BMP2), BMP4 and BMP receptors in the bovine ovary but absence of effects of BMP2 and BMP4 during IVM on bovine oocyte nuclear maturation and subsequent embryo development. Fatehi, A.N., van den Hurk, R., Colenbrander, B., Daemen, A.J., van Tol, H.T., Monteiro, R.M., Roelen, B.A., Bevers, M.M. Theriogenology (2005) [Pubmed]
  2. Regulation of ovarian folliculogenesis by IGF and BMP system in domestic animals. Monget, P., Fabre, S., Mulsant, P., Lecerf, F., Elsen, J.M., Mazerbourg, S., Pisselet, C., Monniaux, D. Domest. Anim. Endocrinol. (2002) [Pubmed]
  3. Hormonal regulation of expression of growth differentiation factor-9 receptor type I and II genes in the bovine ovarian follicle. Jayawardana, B.C., Shimizu, T., Nishimoto, H., Kaneko, E., Tetsuka, M., Miyamoto, A. Reproduction (2006) [Pubmed]
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