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Gene Review

BMPR1B  -  bone morphogenetic protein receptor, type IB

Homo sapiens

Synonyms: ALK-6, ALK6, BMP type-1B receptor, BMPR-1B, Bone morphogenetic protein receptor type-1B, ...
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High impact information on BMPR1B

  • In one family, we identified a T599 --> A mutation changing an isoleucine into a lysine residue (I200K) within the glycine/serine (GS) domain of BMPR1B, a region involved in phosphorylation of the receptor [1].
  • In the other family we identified a C1456 --> T mutation leading to an arginine-to-tryptophan amino acid change (R486W) in a highly conserved region C-terminal of the BMPR1B kinase domain [1].
  • However, endoglin binds BMP-2 by interacting with the ligand binding type I receptors, ALK3 and ALK6 [2].
  • Although Id-1 response was not stimulated by BMP-2 in control PASMCs, the gene delivery of wild-type ALK-6 caused significant increase in the Id-1 transcripts in response to BMP-2 [3].
  • Overexpression of a dominant-negative ALK-6 construct revealed that ALK-6 plays a key role in the mitosis as well as intracellular BMP signaling of pphPASMCs [3].

Biological context of BMPR1B

  • Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23-->q24 byin situ hybridization and radiation hybrid map ping [4].
  • A novel R486Q mutation in BMPR1B resulting in either a brachydactyly type C/symphalangism-like phenotype or brachydactyly type A2 [5].
  • Heterozygous missense mutations in the serine-threonine kinase receptor BMPR1B result typically in brachydactyly type A2 (BDA2), whereas mutations in the corresponding ligand GDF5 cause brachydactyly type C (BDC) [5].
  • To investigate the consequences of the BMPR1B mutations on the intracellular signal transduction, we used stably transfected C2C12 cells and measured the activity of SMAD-dependent and SMAD-independent pathways [5].
  • Disturbances of NOG-GDF5-BMPR1B signaling cascade can result in similar clinical manifestations depending on the quantitative effect and mode of action of the specific mutations within the same functional pathway.European Journal of Human Genetics (2006) 14, 1248-1254. doi:10.1038/sj.ejhg.5201708; published online 6 September 2006 [5].

Anatomical context of BMPR1B


Other interactions of BMPR1B

  • Since overexpression of BMPR1A and BMPR1B, but not SMADs, significantly enhanced the BMP responses, these type I receptors were revealed to be limiting factors for BMP signaling in KGN cells [10].
  • The sections were rehydrated, submitted to microwave antigen retrieval and treated with polyclonal antibodies against BMPR1A, BMPR1B and BMPR2 [11].
  • Gene silencing of ALK-6 using small interfering RNA also reduced DNA synthesis as well as Id-1 transcription in pphPASMCs regardless of BMP-2 stimulation [3].
  • SB-525334 was inactive as an inhibitor of ALK2, ALK3, and ALK6 (IC(50) > 10,000 nM) [12].
  • Interestingly, no response to BMP-4 was observed when cells were transfected with the FecB(B) form of the BMPR1B receptor [7].


  1. Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2. Lehmann, K., Seemann, P., Stricker, S., Sammar, M., Meyer, B., Süring, K., Majewski, F., Tinschert, S., Grzeschik, K.H., Müller, D., Knaus, P., Nürnberg, P., Mundlos, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. Barbara, N.P., Wrana, J.L., Letarte, M. J. Biol. Chem. (1999) [Pubmed]
  3. Characterization of the bone morphogenetic protein (BMP) system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary pulmonary hypertension: roles of BMP type IB receptor (activin receptor-like kinase-6) in the mitotic action. Takeda, M., Otsuka, F., Nakamura, K., Inagaki, K., Suzuki, J., Miura, D., Fujio, H., Matsubara, H., Date, H., Ohe, T., Makino, H. Endocrinology (2004) [Pubmed]
  4. Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23-->q24 byin situ hybridization and radiation hybrid map ping. Ide, H., Saito-Ohara, F., Ohnami, S., Osada, Y., Ikeuchi, T., Yoshida, T., Terada, M. Cytogenet. Cell Genet. (1998) [Pubmed]
  5. A novel R486Q mutation in BMPR1B resulting in either a brachydactyly type C/symphalangism-like phenotype or brachydactyly type A2. Lehmann, K., Seemann, P., Boergermann, J., Morin, G., Reif, S., Knaus, P., Mundlos, S. Eur. J. Hum. Genet. (2006) [Pubmed]
  6. Chromosomal localization of three human genes encoding bone morphogenetic protein receptors. Aström, A.K., Jin, D., Imamura, T., Röijer, E., Rosenzweig, B., Miyazono, K., ten Dijke, P., Stenman, G. Mamm. Genome (1999) [Pubmed]
  7. The Booroola mutation in sheep is associated with an alteration of the bone morphogenetic protein receptor-IB functionality. Fabre, S., Pierre, A., Pisselet, C., Mulsant, P., Lecerf, F., Pohl, J., Monget, P., Monniaux, D. J. Endocrinol. (2003) [Pubmed]
  8. Functional roles of the bone morphogenetic protein system in thyrotropin signaling in porcine thyroid cells. Suzuki, J., Otsuka, F., Takeda, M., Inagaki, K., Miyoshi, T., Mimura, Y., Ogura, T., Doihara, H., Makino, H. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  9. Expression of bone morphogenetic proteins in stromal cells from human bone marrow long-term culture. Martinovic, S., Mazic, S., Kisic, V., Basic, N., Jakic-Razumovic, J., Borovecki, F., Batinic, D., Simic, P., Grgurevic, L., Labar, B., Vukicevic, S. J. Histochem. Cytochem. (2004) [Pubmed]
  10. Mutual regulation of follicle-stimulating hormone signaling and bone morphogenetic protein system in human granulosa cells. Miyoshi, T., Otsuka, F., Suzuki, J., Takeda, M., Inagaki, K., Kano, Y., Otani, H., Mimura, Y., Ogura, T., Makino, H. Biol. Reprod. (2006) [Pubmed]
  11. Effect of bone morphogenetic protein 2 (BMP2) on oestradiol and inhibin A production by sheep granulosa cells, and localization of BMP receptors in the ovary by immunohistochemistry. Souza, C.J., Campbell, B.K., McNeilly, A.S., Baird, D.T. Reproduction (2002) [Pubmed]
  12. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. Grygielko, E.T., Martin, W.M., Tweed, C., Thornton, P., Harling, J., Brooks, D.P., Laping, N.J. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
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