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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

lap  -  like-AP180

Drosophila melanogaster

Synonyms: AP180, BcDNA:GM10787, CG2520, Dmel\CG2520, EP(3)3060, ...
 
 
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High impact information on lap

  • A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis [1].
  • This endocytic process requires AP180 (or a homolog), which promotes the assembly and restricts the size of clathrin-coated vesicles [1].
  • These results provide novel insights into the molecular mechanism of endocytosis and reveal a role for AP180 in regulating vesicle size through a clathrin-dependent reassembly process [2].
  • We are calling this complex AP-3, a name that has also been used for the neuronalspecific phosphoprotein AP180, but we feel that it is a more appropriate designation for an adaptor-related heterotetramer [3].
  • AP180 maintains the distribution of synaptic and vesicle proteins in the nerve terminal and indirectly regulates the efficacy of Ca2+-triggered exocytosis [4].
 

Other interactions of lap

  • Here, we show that a mutation that eliminates an AP180 homolog (LAP) in Drosophila severely impairs the efficiency of synaptic vesicle endocytosis and alters the normal localization of clathrin in nerve terminals [2].

References

  1. A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis. Mao, Y., Chen, J., Maynard, J.A., Zhang, B., Quiocho, F.A. Cell (2001) [Pubmed]
  2. Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis. Zhang, B., Koh, Y.H., Beckstead, R.B., Budnik, V., Ganetzky, B., Bellen, H.J. Neuron (1998) [Pubmed]
  3. Characterization of the adaptor-related protein complex, AP-3. Simpson, F., Peden, A.A., Christopoulou, L., Robinson, M.S. J. Cell Biol. (1997) [Pubmed]
  4. AP180 maintains the distribution of synaptic and vesicle proteins in the nerve terminal and indirectly regulates the efficacy of Ca2+-triggered exocytosis. Bao, H., Daniels, R.W., MacLeod, G.T., Charlton, M.P., Atwood, H.L., Zhang, B. J. Neurophysiol. (2005) [Pubmed]
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