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Gene Review

PICALM  -  phosphatidylinositol binding clathrin...

Homo sapiens

Synonyms: CALM, CLTH, Clathrin assembly lymphoid myeloid leukemia protein, LAP, Phosphatidylinositol-binding clathrin assembly protein
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Disease relevance of PICALM


High impact information on PICALM


Anatomical context of PICALM


  1. Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9. Sindt, A., Deau, B., Brahim, W., Staal, A., Visanica, S., Villarese, P., Rault, J.P., Macintyre, E., Delabesse, E. Genes Chromosomes Cancer (2006) [Pubmed]
  2. Identification and molecular characterization of CALM/AF10fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia. Carlson, K.M., Vignon, C., Bohlander, S., Martinez-Climent, J.A., Le Beau, M.M., Rowley, J.D. Leukemia (2000) [Pubmed]
  3. Nucleocytoplasmic shuttling of endocytic proteins. Vecchi, M., Polo, S., Poupon, V., van de Loo, J.W., Benmerah, A., Di Fiore, P.P. J. Cell Biol. (2001) [Pubmed]
  4. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. Dreyling, M.H., Martinez-Climent, J.A., Zheng, M., Mao, J., Rowley, J.D., Bohlander, S.K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. Tebar, F., Bohlander, S.K., Sorkin, A. Mol. Biol. Cell (1999) [Pubmed]
  6. A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein. Wechsler, D.S., Engstrom, L.D., Alexander, B.M., Motto, D.G., Roulston, D. Genes Chromosomes Cancer (2003) [Pubmed]
  7. MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis. Dreyling, M.H., Schrader, K., Fonatsch, C., Schlegelberger, B., Haase, D., Schoch, C., Ludwig, W., Löffler, H., Büchner, T., Wörmann, B., Hiddemann, W., Bohlander, S.K. Blood (1998) [Pubmed]
  8. Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation. Meyerholz, A., Hinrichsen, L., Groos, S., Esk, P.C., Brandes, G., Ungewickell, E.J. Traffic (2005) [Pubmed]
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