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Gene Review:

Picalm - phosphatidylinositol binding clathrin...

Rattus norvegicus

Synonyms: Calm, Clathrin assembly lymphoid myeloid leukemia protein, Phosphatidylinositol-binding clathrin assembly protein, rCALM

Kim, H.L. et al., Ford, M.G. et al., Yao, P.J. et al.

Kim, Lee, Yao, Petralia, Bushlin, Wang, Furukawa,

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High impact information on Picalm

Adaptor protein 180 (AP180) and its homolog, clathrin assembly lymphoid myeloid leukemia protein (CALM), are closely related proteins that play important roles in clathrin-mediated endocytosis [1].
AP180 and clathrin assembly lymphoid myeloid leukemia protein (CALM) are clathrin accessory proteins that promote the formation of clathrin-coated vesicles [2].
The clathrin assembly protein gene (rCALM) was cloned from rat brain cDNA library. rCALM deduced 69 kD molecule has overall 73% amino acid homology compared with that of AP180 protein [3].

Biological context of Picalm

These results suggest that the rCALM mediates the assembly of clathrin in neural and supporting cells of brain, and regulates the clathrin coated-vesicle formation through phosphorylation and inositide metabolism [3].

Analytical, diagnostic and therapeutic context of Picalm

Molecular cloning of clathrin assembly protein gene (rCALM) and its differential expression to AP180 in rat brain [3].
The mRNA expression of rCALM and AP180 by in situ hybridization histochemistry revealed that the rCALM mRNA was more intensely expressed than that of AP180, and the distribution patterns were different from each other [3].

References

Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes. Ford, M.G., Pearse, B.M., Higgins, M.K., Vallis, Y., Owen, D.J., Gibson, A., Hopkins, C.R., Evans, P.R., McMahon, H.T. Science (2001) [Pubmed]
Synaptic distribution of the endocytic accessory proteins AP180 and CALM. Yao, P.J., Petralia, R.S., Bushlin, I., Wang, Y., Furukawa, K. J. Comp. Neurol. (2005) [Pubmed]
Molecular cloning of clathrin assembly protein gene (rCALM) and its differential expression to AP180 in rat brain. Kim, H.L., Lee, S.C. Exp. Mol. Med. (1999) [Pubmed]

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