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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PGRP-LB  -  Peptidoglycan recognition protein LB

Drosophila melanogaster

Synonyms: CG14704, Dmel\CG14704, Peptidoglycan-recognition protein LB
 
 
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Disease relevance of PGRP-LB

 

High impact information on PGRP-LB

  • (2006) show that PGRP-LB controls systemic immune responses as well as homeostasis at the barrier surfaces [2].
  • Here the crystal structure of Drosophila PGRP-LB is determined at a resolution of 2.0 A and shows an active-site cleft with a zinc cage [3].
  • The serine/histidine juxtaposition to a threonine residue and a carbonyl oxygen atom, along with conservation of the catalytic water molecule found in PGRP-LB, tantalizingly suggests some hydrolytic function for this member of receptor PGRPs [4].

References

  1. The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Zaidman-Rémy, A., Hervé, M., Poidevin, M., Pili-Floury, S., Kim, M.S., Blanot, D., Oh, B.H., Ueda, R., Mengin-Lecreulx, D., Lemaitre, B. Immunity (2006) [Pubmed]
  2. PGRP-LB minds the fort. Girardin, S.E., Philpott, D.J. Immunity (2006) [Pubmed]
  3. Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster. Kim, M.S., Byun, M., Oh, B.H. Nat. Immunol. (2003) [Pubmed]
  4. Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution. Reiser, J.B., Teyton, L., Wilson, I.A. J. Mol. Biol. (2004) [Pubmed]
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