Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

CL46 - collectin -46

Bos taurus

Dec, M. et al., Hansen, S. et al., Gjerstorff, M. et al.

Dec, Wernicki,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on CL-46

CL-46, a novel collectin highly expressed in bovine thymus and liver [1].
CL-46 has two cysteine residues in the N-terminal segment, a potential N-glycosylation site in the collagen region, and an extended hydrophilic loop close to the binding site of the carbohydrate recognition domain [1].
The gene localizes to the same locus as the conglutinin gene on Bos taurus chromosome 28 at position q1.8, which also includes the genes encoding CL-43 and CL-46 [2].
Northern blot or immunocytochemical analysis confirm biosynthesis of bovine collectins mainly in the liver (conglutinin, CL-43) and in the thymus (CL-46) [3].

Biological context of CL-46

The genes encoding conglutinin, CL-43 and CL-46 are located on the bovine chromosome 28, and phylogenetic analysis indicates their common origin--from the lung surfactant protein D gene [3].

References

CL-46, a novel collectin highly expressed in bovine thymus and liver. Hansen, S., Holm, D., Moeller, V., Vitved, L., Bendixen, C., Reid, K.B., Skjoedt, K., Holmskov, U. J. Immunol. (2002) [Pubmed]
Genomic and molecular characterization of bovine surfactant protein D (SP-D). Gjerstorff, M., Madsen, J., Bendixen, C., Holmskov, U., Hansen, S. Mol. Immunol. (2004) [Pubmed]
Conglutinin, CL-43 and CL-46--three bovine collectins. Dec, M., Wernicki, A. Polish journal of veterinary sciences (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SFTPD	Bos taurus
CGN1	Bos taurus
SFTPD	Canis lupus familiaris
SFTPD	Homo sapiens
SFTPD	Macaca mulatta
Sftpd	Mus musculus
SFTPD	Pan troglodytes
Sftpd	Rattus norvegicus
LOC100135366	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.